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- W4312243968 abstract "The angiotensin-converting enzyme docks onto the spike glycoprotein on the virion outward. The dimer of the enzyme{ACE}2 is an vital step in the mechanism of life-threatening acute respiratory failure. Human cells are infected with the syndrome coronavirus 2 (SARS-CoV-2).The systemic renin-angiotensin system stifles the expression of ACE2 (RAS) imbalance and advancement of multi-organ harm. In common, the RAS triggers vasoconstriction, hypertension, inflammation, fibrosis, and proliferation through the ACE/Ang II/Ang II type 1 receptor (AT1R) axis and triggers the switch impacts through the ACE2/ Ang (1-7)/Mas axis. The RAS may be triggered by chronic inflammation in hypertension, diabetes, heavy weight, and cancer. The ACE 2 /Ang {1-7} / Mas axis is deactivated by means of SARS-CoV-2-induced ACE2 internalization and shedding. As a result, we believe that two RAS hits are responsible for COVID-19 progression. In summary, the The ACE / Ang II/ AT1R axis is triggered by chronic inflammation, which is the first hit. The second stems from the disruption of the ACE2/Ang (1-7)/Mas axis by COVID-19 infection. Furthermore, the two RAS hits might be the primary cause of elevated numbers of death in COVID-19 patients and comorbidities, and they might be used as a clinical target for COVID-19 therapy." @default.
- W4312243968 created "2023-01-04" @default.
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- W4312243968 date "2022-01-01" @default.
- W4312243968 modified "2023-09-26" @default.
- W4312243968 title "The role of the renin–angiotensin system in the pathogenesis of COVID-19" @default.
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- W4312243968 doi "https://doi.org/10.1063/5.0121763" @default.
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