Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312273670> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4312273670 endingPage "75" @default.
- W4312273670 startingPage "68" @default.
- W4312273670 abstract "A1 domain of von Willebrand factor (VWF) binding with platelet glycoprotein (GP) Ibα play crucial roles in platelet adhesion and subsequent passive shape changes in the platelets such as pseudopod formation under high wall shear rate conditions. However, the effects of specific inhibitors of VWF binding with GPIbα on the length of pseudopods supporting platelet adhesion on VWF are still to be elucidated. Here we measured the length of pseudopods in the presence of VWF-GPIbα inhibitor of caplacizumab. The length of pseudopods was 6.5 ± 0.2 μm (mean ± 95% confidential interval [CI]) and 6.9 ± 0.2 μm (mean ± 95% CI) at 100 and 200 nM of caplacizumab concentrations and was longer than those formed in its absence (5.2 ± 0.2 μm, p < 0.05). Our experiments also revealed that the surface area coverage by platelets in the presence of caplacizumab at a concentration of 200 nM of 26.1 ± 6.4% after 60-second blood perfusion was smaller than its absence (45.2 ± 7.5%, p < 0.05). Our results suggest that fewer numbers of VWF-GPIbα bonds generating larger binding force with a longer length of pseudopods, support the platelet adhesion on VWF in the presence of caplacizumab at a wall shear rate of 1,500 s–1." @default.
- W4312273670 created "2023-01-04" @default.
- W4312273670 creator A5044476123 @default.
- W4312273670 creator A5084980436 @default.
- W4312273670 date "2022-01-01" @default.
- W4312273670 modified "2023-09-28" @default.
- W4312273670 title "Effects of caplacizumab, a specific inhibitor of the A1 domain of von Willebrand factor binding with platelet membrane glycoprotein (GP) Ibα, on the length of platelet pseudopods supporting platelet adhesions on immobilized von Willebrand factor under blood flow condition" @default.
- W4312273670 cites W1803512301 @default.
- W4312273670 cites W1905796107 @default.
- W4312273670 cites W1963549684 @default.
- W4312273670 cites W1972947242 @default.
- W4312273670 cites W1982402950 @default.
- W4312273670 cites W1993486440 @default.
- W4312273670 cites W1997124038 @default.
- W4312273670 cites W1998596396 @default.
- W4312273670 cites W2022755299 @default.
- W4312273670 cites W2023298935 @default.
- W4312273670 cites W2025016935 @default.
- W4312273670 cites W2042759990 @default.
- W4312273670 cites W2045737112 @default.
- W4312273670 cites W2047204651 @default.
- W4312273670 cites W2049017817 @default.
- W4312273670 cites W2051957959 @default.
- W4312273670 cites W2060935167 @default.
- W4312273670 cites W2062563200 @default.
- W4312273670 cites W2069595388 @default.
- W4312273670 cites W2073397889 @default.
- W4312273670 cites W2075013504 @default.
- W4312273670 cites W2090679041 @default.
- W4312273670 cites W2122719023 @default.
- W4312273670 cites W2123737096 @default.
- W4312273670 cites W2125963595 @default.
- W4312273670 cites W2128493116 @default.
- W4312273670 cites W2164670366 @default.
- W4312273670 cites W2289161043 @default.
- W4312273670 cites W2320387098 @default.
- W4312273670 cites W2766148464 @default.
- W4312273670 cites W2938048824 @default.
- W4312273670 cites W3037643831 @default.
- W4312273670 cites W3171020397 @default.
- W4312273670 cites W3204388797 @default.
- W4312273670 cites W3211324700 @default.
- W4312273670 cites W4221013946 @default.
- W4312273670 cites W4243615520 @default.
- W4312273670 doi "https://doi.org/10.17106/jbr.36.68" @default.
- W4312273670 hasPublicationYear "2022" @default.
- W4312273670 type Work @default.
- W4312273670 citedByCount "0" @default.
- W4312273670 crossrefType "journal-article" @default.
- W4312273670 hasAuthorship W4312273670A5044476123 @default.
- W4312273670 hasAuthorship W4312273670A5084980436 @default.
- W4312273670 hasBestOaLocation W43122736701 @default.
- W4312273670 hasConcept C12554922 @default.
- W4312273670 hasConcept C126322002 @default.
- W4312273670 hasConcept C134018914 @default.
- W4312273670 hasConcept C1491633281 @default.
- W4312273670 hasConcept C153911025 @default.
- W4312273670 hasConcept C185592680 @default.
- W4312273670 hasConcept C199528912 @default.
- W4312273670 hasConcept C26828662 @default.
- W4312273670 hasConcept C2779394231 @default.
- W4312273670 hasConcept C2910597130 @default.
- W4312273670 hasConcept C55493867 @default.
- W4312273670 hasConcept C71924100 @default.
- W4312273670 hasConcept C86803240 @default.
- W4312273670 hasConcept C89560881 @default.
- W4312273670 hasConceptScore W4312273670C12554922 @default.
- W4312273670 hasConceptScore W4312273670C126322002 @default.
- W4312273670 hasConceptScore W4312273670C134018914 @default.
- W4312273670 hasConceptScore W4312273670C1491633281 @default.
- W4312273670 hasConceptScore W4312273670C153911025 @default.
- W4312273670 hasConceptScore W4312273670C185592680 @default.
- W4312273670 hasConceptScore W4312273670C199528912 @default.
- W4312273670 hasConceptScore W4312273670C26828662 @default.
- W4312273670 hasConceptScore W4312273670C2779394231 @default.
- W4312273670 hasConceptScore W4312273670C2910597130 @default.
- W4312273670 hasConceptScore W4312273670C55493867 @default.
- W4312273670 hasConceptScore W4312273670C71924100 @default.
- W4312273670 hasConceptScore W4312273670C86803240 @default.
- W4312273670 hasConceptScore W4312273670C89560881 @default.
- W4312273670 hasIssue "2" @default.
- W4312273670 hasLocation W43122736701 @default.
- W4312273670 hasOpenAccess W4312273670 @default.
- W4312273670 hasPrimaryLocation W43122736701 @default.
- W4312273670 hasRelatedWork W1227255805 @default.
- W4312273670 hasRelatedWork W2085718822 @default.
- W4312273670 hasRelatedWork W2087754560 @default.
- W4312273670 hasRelatedWork W2308864913 @default.
- W4312273670 hasRelatedWork W2405499513 @default.
- W4312273670 hasRelatedWork W2411921922 @default.
- W4312273670 hasRelatedWork W2412411801 @default.
- W4312273670 hasRelatedWork W296184847 @default.
- W4312273670 hasRelatedWork W4231973826 @default.
- W4312273670 hasRelatedWork W4235257442 @default.
- W4312273670 hasVolume "36" @default.
- W4312273670 isParatext "false" @default.
- W4312273670 isRetracted "false" @default.
- W4312273670 workType "article" @default.