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- W4312277079 abstract "In amyotrophic lateral sclerosis (ALS) prognosis is limited by insufficiency of respiratory muscles. It may be improved by noninvasive ventilation (NIV), initially at nighttime. The indication is based on pulmonary function testing (PFT) and polysomography (PSG) with capnography (tCO2). It is still open, which awake parameters are predictable for nocturnal ventilation. We analyzed PFT (spirometry, plethysmography, DLCO, respir. muscle testing, blood gases, PSG and tCO2 in 42 ALS-pts (27 men, 15 women, age 69 ± 12,1 y) retrospectively. 25 Patients (64%) showed restrictive impairment of ventilation and 15 (48,3%) insufficiency of respiratory musculature (P01/Pimax = 5,6 ± 3,3%; Pimax 40,5 ± 15,4 %Pred; Pemax 56,6 ± 26,9%Pred). We observed strong correlations between daytime inspiratory parameters, as well as DLCO, and FEV1/FVC even in the absence of obstruction with nocturnal hypercapnia. Furthermore, awake hypercapnia and bicarbonate and base excess were positively correlated with nocturnal hypercapnia. In summary, these results indicate, that the prediction of nocturnal ventilation by daytime PFT is limited. Inspiratory parameters performed better than others. This confirms the relevance of inspiratory muscle weakness in ALS. The interpretation of PFT in ALS should focus on inspiratory parameters. PSG and tCO2remain the gold standard for the assessment of nocturnal ventilation." @default.
- W4312277079 created "2023-01-04" @default.
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- W4312277079 date "2022-09-04" @default.
- W4312277079 modified "2023-09-27" @default.
- W4312277079 title "Prediction of Nocturnal Ventilation by Pulmonary Function Testing in Patients with Amyotrophic Lateral Sclerosis (ALS)." @default.
- W4312277079 doi "https://doi.org/10.1183/13993003.congress-2022.904" @default.
- W4312277079 hasPublicationYear "2022" @default.
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