Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312282912> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4312282912 abstract "Background: Left ventricular pressure overload (LVPO) can develop from antecedent conditions, like aortic stenosis, and is associated with increased myocardial collagen content that can lead to increases in myocardial stiffness. Alleviation of LVPO in patients undergoing surgical aortic valve replacement (SAVR) resulted in reduced but persistent fibrosis evident in biopsies taken 5-yrs following SAVR. Little is known regarding cellular mechanisms that contribute to ECM turnover following hemodynamic unloading. Objective: Determine the time course of ECM remodeling after alleviation of LVPO. Methods: Transverse aortic constriction (TAC) was used to induce LVPO. Following 4wks of TAC, alleviation of LVPO was performed by removing the TAC band (unTAC). Five time points were assessed: Control no TAC, 4wk TAC, 4wk TAC+2wk unTAC, 4wk TAC+4wk unTAC, and 4wk TAC+6wk unTAC for cardiomyocyte cross-sectional area (CSA), collagen volume fraction (CVF), collagen degradation, and myocardial stiffness. Results: CSA increased by 47% at 4wk TAC vs control. Compared to 4wk TAC, CSA decreased by 20% at 2wk unTAC, but returned to control levels by 6wk unTAC. CVF increased by 204% at 4wk TAC vs control. Although CVF was similar between 4wk TAC and 2wk unTAC, 2wk unTAC demonstrated robust increases in markers of collagen degradation (cathepsin K, pro-matrix metalloproteinase 2 (pro-MMP2), MMP3, and MMP8). CVF significantly decreased at 4wk unTAC compared to 2wk unTAC. However, the markers of collagen degradation were reduced by 4wk- and 6wk unTAC likely contributing to persistent fibrosis. Furthermore, passive stiffness remained elevated at 6wk unTAC. Conclusion: In LVPO hearts, hypertrophy and fibrosis were present. Although cardiomyocyte hypertrophy fully regressed with normalization of hemodynamic load, increased myocardial stiffness and elevated interstitial fibrosis were persistent." @default.
- W4312282912 created "2023-01-04" @default.
- W4312282912 creator A5006260189 @default.
- W4312282912 creator A5014049392 @default.
- W4312282912 creator A5047833899 @default.
- W4312282912 creator A5053390482 @default.
- W4312282912 creator A5059038468 @default.
- W4312282912 date "2022-08-05" @default.
- W4312282912 modified "2023-09-24" @default.
- W4312282912 title "Abstract P2051: Incomplete Regression And Persistence Of Interstitial Fibrosis Following Removal Of Left Ventricular Pressure Overload" @default.
- W4312282912 doi "https://doi.org/10.1161/res.131.suppl_1.p2051" @default.
- W4312282912 hasPublicationYear "2022" @default.
- W4312282912 type Work @default.
- W4312282912 citedByCount "0" @default.
- W4312282912 crossrefType "journal-article" @default.
- W4312282912 hasAuthorship W4312282912A5006260189 @default.
- W4312282912 hasAuthorship W4312282912A5014049392 @default.
- W4312282912 hasAuthorship W4312282912A5047833899 @default.
- W4312282912 hasAuthorship W4312282912A5053390482 @default.
- W4312282912 hasAuthorship W4312282912A5059038468 @default.
- W4312282912 hasConcept C126322002 @default.
- W4312282912 hasConcept C2778198053 @default.
- W4312282912 hasConcept C2778271984 @default.
- W4312282912 hasConcept C2780559512 @default.
- W4312282912 hasConcept C3018791406 @default.
- W4312282912 hasConcept C71924100 @default.
- W4312282912 hasConcept C98274493 @default.
- W4312282912 hasConceptScore W4312282912C126322002 @default.
- W4312282912 hasConceptScore W4312282912C2778198053 @default.
- W4312282912 hasConceptScore W4312282912C2778271984 @default.
- W4312282912 hasConceptScore W4312282912C2780559512 @default.
- W4312282912 hasConceptScore W4312282912C3018791406 @default.
- W4312282912 hasConceptScore W4312282912C71924100 @default.
- W4312282912 hasConceptScore W4312282912C98274493 @default.
- W4312282912 hasIssue "Suppl_1" @default.
- W4312282912 hasLocation W43122829121 @default.
- W4312282912 hasOpenAccess W4312282912 @default.
- W4312282912 hasPrimaryLocation W43122829121 @default.
- W4312282912 hasRelatedWork W2015734123 @default.
- W4312282912 hasRelatedWork W2064525822 @default.
- W4312282912 hasRelatedWork W2078921687 @default.
- W4312282912 hasRelatedWork W2115795314 @default.
- W4312282912 hasRelatedWork W2159692800 @default.
- W4312282912 hasRelatedWork W2339946083 @default.
- W4312282912 hasRelatedWork W2414489230 @default.
- W4312282912 hasRelatedWork W2566561968 @default.
- W4312282912 hasRelatedWork W4225416407 @default.
- W4312282912 hasRelatedWork W4247718175 @default.
- W4312282912 hasVolume "131" @default.
- W4312282912 isParatext "false" @default.
- W4312282912 isRetracted "false" @default.
- W4312282912 workType "article" @default.