Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312290416> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4312290416 endingPage "522" @default.
- W4312290416 startingPage "522" @default.
- W4312290416 abstract "Background: The treatment in organic catatonia includes benzodiazepines, ECT and treatment of underlying condition. In a pilot study1, Lorazepam produced sedation, hypotension and respiratory depression. Tofisopam, (FDA approved for IBS2) was safe and effective which can be a treatment alternative. This study was designed to study the efficacy and adverse effects of Tofisopam in organic catatonia. Materials and Methods: This study included 60 patients irrespective of age and gender with diagnosis of Organic Catatonia (F061, ICD-10). Patients with Delirium, Psychiatric illness and SUD were excluded. Busch Francis Catatonia Rating Scale (BFCRS) was used to assess the features of catatonia at baseline and at 48 to 72 hours. Tofisopam 50-100mg/day was administered. Changes in BP, RR, spO2 and GCS was noted. Paired T test, Chi square test, Pearson’s correlation and SPSS 17 was used. Results and Discussion: The mean age was 54.27 ± 16.5 years with 46 males and 14 females. The mean baseline score in BFCRS was 11.73+-1.31. Out of 60 patients, 44 (71%) had response. Response was defined as reduction of catatonic signs to 1 or none on 14 item BFCRS3. Response occurred in CKD, Parkinsonism, Hypertensive encephalopathy, post-CABG and post-GI surgery patients. No response occurred in Septicemia, CKD with Multi-organ Failure. The domains with significant response were Stupor, Mutism, Staring, Posturing, Rigidity, Negativism and Withdrawal without significant side-effects. Tofisopam (mixed dopamine agonist- antagonist)4 modulates the hypo-dopaminergic state in catatonia. Its non-sedative, non-hypotensive5 property can explain the added advantage over lorazepam. Conclusion: Tofisopam can be a safe and effective alternative treatment in Organic Catatonia." @default.
- W4312290416 created "2023-01-04" @default.
- W4312290416 date "2022-01-01" @default.
- W4312290416 modified "2023-10-18" @default.
- W4312290416 title "Young Psychiatrist Award" @default.
- W4312290416 doi "https://doi.org/10.4103/0019-5545.341494" @default.
- W4312290416 hasPublicationYear "2022" @default.
- W4312290416 type Work @default.
- W4312290416 citedByCount "0" @default.
- W4312290416 crossrefType "journal-article" @default.
- W4312290416 hasBestOaLocation W43122904161 @default.
- W4312290416 hasConcept C118552586 @default.
- W4312290416 hasConcept C126322002 @default.
- W4312290416 hasConcept C15744967 @default.
- W4312290416 hasConcept C2776412080 @default.
- W4312290416 hasConcept C2776525014 @default.
- W4312290416 hasConcept C2776814716 @default.
- W4312290416 hasConcept C2778941822 @default.
- W4312290416 hasConcept C2779134260 @default.
- W4312290416 hasConcept C2779706987 @default.
- W4312290416 hasConcept C2779753318 @default.
- W4312290416 hasConcept C2780852908 @default.
- W4312290416 hasConcept C2780939311 @default.
- W4312290416 hasConcept C42219234 @default.
- W4312290416 hasConcept C71924100 @default.
- W4312290416 hasConceptScore W4312290416C118552586 @default.
- W4312290416 hasConceptScore W4312290416C126322002 @default.
- W4312290416 hasConceptScore W4312290416C15744967 @default.
- W4312290416 hasConceptScore W4312290416C2776412080 @default.
- W4312290416 hasConceptScore W4312290416C2776525014 @default.
- W4312290416 hasConceptScore W4312290416C2776814716 @default.
- W4312290416 hasConceptScore W4312290416C2778941822 @default.
- W4312290416 hasConceptScore W4312290416C2779134260 @default.
- W4312290416 hasConceptScore W4312290416C2779706987 @default.
- W4312290416 hasConceptScore W4312290416C2779753318 @default.
- W4312290416 hasConceptScore W4312290416C2780852908 @default.
- W4312290416 hasConceptScore W4312290416C2780939311 @default.
- W4312290416 hasConceptScore W4312290416C42219234 @default.
- W4312290416 hasConceptScore W4312290416C71924100 @default.
- W4312290416 hasIssue "9" @default.
- W4312290416 hasLocation W43122904161 @default.
- W4312290416 hasLocation W43122904162 @default.
- W4312290416 hasLocation W43122904163 @default.
- W4312290416 hasLocation W43122904164 @default.
- W4312290416 hasOpenAccess W4312290416 @default.
- W4312290416 hasPrimaryLocation W43122904161 @default.
- W4312290416 hasRelatedWork W2024991442 @default.
- W4312290416 hasRelatedWork W207743446 @default.
- W4312290416 hasRelatedWork W2087677505 @default.
- W4312290416 hasRelatedWork W2153360178 @default.
- W4312290416 hasRelatedWork W2332257496 @default.
- W4312290416 hasRelatedWork W2434195530 @default.
- W4312290416 hasRelatedWork W2596595674 @default.
- W4312290416 hasRelatedWork W2616746715 @default.
- W4312290416 hasRelatedWork W4286111624 @default.
- W4312290416 hasRelatedWork W4300615286 @default.
- W4312290416 hasVolume "64" @default.
- W4312290416 isParatext "false" @default.
- W4312290416 isRetracted "false" @default.
- W4312290416 workType "article" @default.