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• W4312302899 abstract "<b>Background:</b> COPD and OSA have been associated with low vitamin D (Vit D) serum levels but there are limited data regarding Vit D status in patients with coexistent COPD and OSA (overlap syndrome-OVS). Additionally, low vit D levels may be linked with increased cardiovascular risk and COPD exacerbations. <b>Aim:</b> The aim of the study was to compare Vit D serum levels between patients with OVS, patients with OSA and controls and to explore associations with anthropometric, respiratory and sleep parameters. <b>Methods:</b> Vit D serum levels [assessed by 25(OH)D levels] were measured in 3 prospectively recruited age-, gender-, and BMI-matched groups of patients with OVS, patients with OSA, and controls as verified by overnight polysomnography and PFTs. COPD diagnosis was based on symptoms and a post-bronchodilator FEV1/FVC<0.7; while OSA diagnosis was based on apnea-hypopnea index (AHI)≥5/h along with symptoms. Subjects with AHI<5/h and normal PFTs were considered as controls. Each group included 30 individuals. <b>Results:</b> Patients with OVS exhibited decreased serum 25(OH)D levels compared with OSA patients [14.5 (12.3–17.9) vs 18.6 (13.2–25.2) ng/ml respectively, p<0.05] and controls [21.6 (17.8–33.6) ng/ml, p<0.001]. Multiple linear regression analysis identified an association between AHI (β=-0.758, p=0.041) and FEV1 (β=0.698, p=0.038) with serum Vit D levels, in the OVS group. <b>Conclusions:</b> Patients with OVS exhibit significant lower Vit D levels; stronger predictors were AHI and FEV1. Given potential associations between Vit D deficiency and cardiovascular disease and COPD exacerbations, it may be useful its measurement and treatment; however more studies are needed." @default.
• W4312302899 created "2023-01-04" @default.
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• W4312302899 date "2022-09-04" @default.
• W4312302899 modified "2023-09-23" @default.
• W4312302899 title "Comparison of serum vitamin D levels in patients with Overlap Syndrome, patients with pure Obstructive Sleep Apnea, and controls" @default.
• W4312302899 doi "https://doi.org/10.1183/13993003.congress-2022.2705" @default.
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