FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312308035> ?p ?o ?g. }

• W4312308035 endingPage "176" @default.
• W4312308035 startingPage "163" @default.
• W4312308035 abstract "Role of radiotherapy (RT) in the era of immuno-oncology (IO) in advanced non-small cell lung cancer (NSCLC) is rapidly changing. RT is not only intended for addressing palliation symptoms but also is considered as a potential tool potentializing an immunogenic effect of given drugs. However, the best timing, techniques, doses, volumes, and its use for asymptomatic patients is a subject of research. We performed a review on the role of palliative RT schedules in combination with IO for advanced NSCLC. Indications in symptomatic and asymptomatic patients, outcomes, toxicity, and possible developments are discussed.A literature search was conducted in MEDLINE and PubMed databases and clinicaltrials.gov using the keywords 'lung cancer' AND immunotherapy AND 'radiotherapy' OR palliative radiotherapy.Body of evidence indicate that palliative RT used in combination with IO is effective in terms of symptom management and safe; does not increase the risk of serious side effects, including serious pulmonary toxicity. We have limited data evidencing improvement of survival by addition of short ablative RT dose to one site of the disease to IO in oligometastatic NSCLC. Some data indicate that short ablative doses of stereotactic body radiation therapy (SBRT) are more effective with regard to treatment response and survival than protracted RT schedule with lower fractional doses. However, this may be a selection bias of better prognostic patients who underwent SBRT. The use of steroids being a potential concern during IO should not be prohibited if clinically indicated during palliative RT. Its detrimental effect shown in some studies may also be a result of selection bias, because steroids given for not cancer-related causes during IO did not decrease survival.RT for symptom management may be used during, directly before or after IO. This has a potential to ease symptom burdens and improve performance status (PS). However, still more studies are needed to establish optimal guidelines in asymptomatic patients for appropriate timing, volumes, dose, and fractionation schedules of palliative RT use in combination with IO." @default.
• W4312308035 created "2023-01-04" @default.
• W4312308035 creator A5065371133 @default.
• W4312308035 date "2023-01-01" @default.
• W4312308035 modified "2023-09-25" @default.
• W4312308035 title "Palliative extracranial radiotherapy in patients receiving immunotherapy for non-small cell lung cancer: a narrative review" @default.
• W4312308035 cites W1668519984 @default.
• W4312308035 cites W1903277992 @default.
• W4312308035 cites W1965887310 @default.
• W4312308035 cites W1979621990 @default.
• W4312308035 cites W1990811913 @default.
• W4312308035 cites W2003574138 @default.
• W4312308035 cites W2012295597 @default.
• W4312308035 cites W2017217585 @default.
• W4312308035 cites W2026650308 @default.
• W4312308035 cites W2037171241 @default.
• W4312308035 cites W2059009104 @default.
• W4312308035 cites W2060475769 @default.
• W4312308035 cites W2065436947 @default.
• W4312308035 cites W2065704766 @default.
• W4312308035 cites W2066559944 @default.
• W4312308035 cites W2068549111 @default.
• W4312308035 cites W2072281108 @default.
• W4312308035 cites W2076773100 @default.
• W4312308035 cites W2077210792 @default.
• W4312308035 cites W2089205578 @default.
• W4312308035 cites W2090558521 @default.
• W4312308035 cites W2147188169 @default.
• W4312308035 cites W2149874552 @default.
• W4312308035 cites W2162808320 @default.
• W4312308035 cites W2163351155 @default.
• W4312308035 cites W2591602708 @default.
• W4312308035 cites W2618641368 @default.
• W4312308035 cites W2761351587 @default.
• W4312308035 cites W2790983120 @default.
• W4312308035 cites W2803766273 @default.
• W4312308035 cites W2901734295 @default.
• W4312308035 cites W2917763666 @default.
• W4312308035 cites W2942040016 @default.
• W4312308035 cites W2944301866 @default.
• W4312308035 cites W2952666958 @default.
• W4312308035 cites W2955348147 @default.
• W4312308035 cites W2956407134 @default.
• W4312308035 cites W2965638931 @default.
• W4312308035 cites W2970142977 @default.
• W4312308035 cites W3009486036 @default.
• W4312308035 cites W3019546741 @default.
• W4312308035 cites W3020551799 @default.
• W4312308035 cites W3032651552 @default.
• W4312308035 cites W3034353821 @default.
• W4312308035 cites W3089564941 @default.
• W4312308035 cites W3092159910 @default.
• W4312308035 cites W3093708469 @default.
• W4312308035 cites W3094884516 @default.
• W4312308035 cites W3102895667 @default.
• W4312308035 cites W3107708922 @default.
• W4312308035 cites W3112921784 @default.
• W4312308035 cites W3148349215 @default.
• W4312308035 cites W3162040459 @default.
• W4312308035 cites W3190923734 @default.
• W4312308035 cites W4206362366 @default.
• W4312308035 cites W4206898533 @default.
• W4312308035 cites W4210289312 @default.
• W4312308035 cites W4210716000 @default.
• W4312308035 cites W4210876233 @default.
• W4312308035 cites W4210992155 @default.
• W4312308035 cites W4213331012 @default.
• W4312308035 cites W4214715663 @default.
• W4312308035 cites W4244503053 @default.
• W4312308035 cites W4282973609 @default.
• W4312308035 cites W4283374461 @default.
• W4312308035 cites W4296523554 @default.
• W4312308035 doi "https://doi.org/10.21037/tcr-22-1969" @default.
• W4312308035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36760380" @default.
• W4312308035 hasPublicationYear "2023" @default.
• W4312308035 type Work @default.
• W4312308035 citedByCount "0" @default.
• W4312308035 crossrefType "journal-article" @default.
• W4312308035 hasAuthorship W4312308035A5065371133 @default.
• W4312308035 hasBestOaLocation W43123080351 @default.
• W4312308035 hasConcept C121608353 @default.
• W4312308035 hasConcept C126322002 @default.
• W4312308035 hasConcept C143998085 @default.
• W4312308035 hasConcept C159110408 @default.
• W4312308035 hasConcept C2776256026 @default.
• W4312308035 hasConcept C2777701055 @default.
• W4312308035 hasConcept C2777910003 @default.
• W4312308035 hasConcept C2994186709 @default.
• W4312308035 hasConcept C509974204 @default.
• W4312308035 hasConcept C71924100 @default.
• W4312308035 hasConceptScore W4312308035C121608353 @default.
• W4312308035 hasConceptScore W4312308035C126322002 @default.
• W4312308035 hasConceptScore W4312308035C143998085 @default.
• W4312308035 hasConceptScore W4312308035C159110408 @default.
• W4312308035 hasConceptScore W4312308035C2776256026 @default.
• W4312308035 hasConceptScore W4312308035C2777701055 @default.
• W4312308035 hasConceptScore W4312308035C2777910003 @default.
• W4312308035 hasConceptScore W4312308035C2994186709 @default.

• next