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- W4312309612 abstract "Stringent criteria in pulmonary arterial hypertension (PAH) trials usually exclude patients ≥75 years. Here we present characteristics, outcomes and safety of macitentan-treated patients of ≥75 years from the US OPUS registry (Apr 2014 – Jun 2020; NCT02126943) and OrPHeUS medical chart review (Oct 2013 – Mar 2017; NCT03197688). In the pooled OPUS/OrPHeUS data there were 4626 new macitentan users with follow-up information (PAH set), of whom 778 (17%) were ≥75 years. Patient characteristics at macitentan initiation are shown in the table. From Kaplan‑Meier (95% CI) estimates in the ≥75 years and PAH set, respectively: 53% (49, 57) and 60% (58, 62) of patients were free from hospitalisation; 84% (81, 87) and 90% (89, 91) were alive at 12 months. In the ≥75 years and PAH set respectively, 410 (53%) and 790 (43%) patients discontinued macitentan: 175 (22%) and 790 (22%) due to an adverse event (AE), 0 and 15 (<1%) due to a hepatic adverse event (HAE), and 168 (22%) and 838 (18%) not due to an AE / HAE. These data reveal that patients ≥75 years are being treated with macitentan as monotherapy or as part of combination therapy, and had similar safety and tolerability profiles to PAH patients. Hospitalisation and survival are aligned with expected rates for an elderly PAH patient group<sup>1</sup>. The treatment of elderly patients with macitentan is well tolerated. 1. Hoeper MM, et al. Int J Cardiol 2013; 168:871-80" @default.
- W4312309612 created "2023-01-04" @default.
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- W4312309612 date "2022-09-04" @default.
- W4312309612 modified "2023-10-18" @default.
- W4312309612 title "Macitentan real-world experience in elderly patients over 75 years with pulmonary arterial hypertension (PAH)" @default.
- W4312309612 doi "https://doi.org/10.1183/13993003.congress-2022.911" @default.
- W4312309612 hasPublicationYear "2022" @default.
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