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- W4312332630 abstract "<b>Introduction:</b> CLAD, the leading cause of death post lung transplantation (LTx), is diagnosed based on persistent drop in FEV1. The two phenotypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), characterized by spirometry and chest imaging, have different prognoses. Osc is an effort-independent measure of pulmonary function more sensitive to small airway dysfunction. <b>Aim:</b> To characterize Osc pattern at CLAD onset. <b>Methods:</b> Of the 273/289 double LTx patients with paired Osc-spirometry and follow-up >6 months, 41/81 patients with CLAD had Osc at CLAD onset. Osc from 179 CLAD-free patients was time matched to each CLAD patient for comparison. <b>Results:</b> CLAD and CLAD-free groups differed in Osc measurement of resistance (R5=4.1 vs 3.5, R5-19=0.97 vs 0.55) and reactance (AX=18.1 vs 9.1, X5=-2.4 vs -1.6) (p<0.05). 31 CLAD cases were clearly identified as BOS (n=24; %TLC=78.0, FEV1/FVC=66.6) or RAS (n= 7; %TLC= 64.9, FEV1/FVC= 85.0). Osc was significantly different between 2 groups with BOS characterized by high R5-19 (1.27 vs. 0.69), reactance (AX=20.9 vs 12.8) and oscillogram pattern characteristic of obstructive lung disease, whereas RAS resembled that of interstitial lung disease (Fig. 1). <b>Conclusions:</b> Osc at time of CLAD onset is significantly different between RAS and BOS and could help phenotype CLAD without chest imaging when used with spirometry." @default.
- W4312332630 created "2023-01-04" @default.
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- W4312332630 date "2022-09-04" @default.
- W4312332630 modified "2023-09-26" @default.
- W4312332630 title "Characterization of chronic lung allograft dysfunction (CLAD) at time onset using respiratory oscillometry (Osc)" @default.
- W4312332630 doi "https://doi.org/10.1183/13993003.congress-2022.1237" @default.
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