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- W4312341996 abstract "Recent developments in genetic technologies for genomic analysis, diagnostics, and therapeutics have revolutionary effects on medical science. Oligonucleotide (ON) molecules play an essential role in managing cellular genetic disorders because of their sequence-specific inhibitory effect on complementary RNAs. ONs with modified nucleosides exhibit higher enzymatic stability, duplex-forming ability, sequence selectivity, and in vivo pharmacokinetic profiles, which are extremely anticipated for ON therapeutics. We previously reported 2′-O,4′-C-methylene bridged nucleic acid/locked nucleic acid (2′,4′-BNA/LNA) with exceptionally high duplex-forming capability toward complementary sequences. In recent years, we have focused on developing further intensified bridged nucleic acids with high enzymatic resistance, sequence specificity, high in vivo efficacy, and low toxicity. Herein, we report numerous promising bridged nucleic acids that have been developed in our laboratory since the introduction of 2′,4′-BNA/LNA." @default.
- W4312341996 created "2023-01-04" @default.
- W4312341996 creator A5078306759 @default.
- W4312341996 creator A5083003749 @default.
- W4312341996 date "2022-01-01" @default.
- W4312341996 modified "2023-09-26" @default.
- W4312341996 title "Bridged Nucleic Acids for Therapeutic Oligonucleotides" @default.
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- W4312341996 doi "https://doi.org/10.1007/978-981-16-1313-5_18-1" @default.
- W4312341996 hasPublicationYear "2022" @default.
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