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- W4312362308 abstract "Seizure is sudden disorganized uncontrolled electrical activity in the brain, leading to alteration of behaviors, movement, or level of consciousness. Due to the varying etiology and presence of various types of seizures, there is a need for specific drugs for each type of seizure. In preclinical trials, drugs are tested on healthy rodents, often male, from uniform living conditions, with uniform etiology and pathology of seizures. The age of onset and duration of disease will be similar. Drugs will be given before the onset of seizures, no other drug will be co-administered, and there will be no previous history of antiepileptic drug intake or comorbidities. Therefore, the drugs which are found to be effective in preclinical studies may not be effective in clinical trials. The currently available screening methods include in-vitro techniques like GABAA and GABAB receptor binding measurement in rat cortex, GABA uptake in rat’s cerebral cortex, modulation of NMDA, glutamate, and glycine receptors by test drugs, and neurotoxicity assays. Screening methods also include various in-vivo techniques like electrically-induced seizure models, chemically induced seizure models, and surgically induced seizure models. Apart from these models, various genetic models of epilepsy have been developed for studying rare types of seizures. This chapter will summarize the basic techniques, calculations, advantages, and disadvantages of screening methods for anti-epileptic activity." @default.
- W4312362308 created "2023-01-04" @default.
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- W4312362308 date "2022-01-01" @default.
- W4312362308 modified "2023-09-27" @default.
- W4312362308 title "Screening Methods for the Evaluation of Antiepileptic Drugs" @default.
- W4312362308 cites W1932830971 @default.
- W4312362308 cites W2014281284 @default.
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- W4312362308 doi "https://doi.org/10.1007/978-981-19-5343-9_14" @default.
- W4312362308 hasPublicationYear "2022" @default.
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