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- W4312364680 abstract "Abstract Temporomandibular disorder (TMD) is a collective term for a group of conditions that lead to impairment of the function of the temporomandibular joint. The proteins/genes and signaling pathways associated with TMD are still poorly understood. The aim of this study was to identify key differentially expressed salivary proteins/genes (DEGs) associated with TMD progression using LC-MS/MS coupled with a bioinformatics approach. The protein–protein interaction network was obtained from the STRING database and the hub genes were identified using Cytoscape including cytoHubba and MCODE plug-ins. In addition, enrichment of gene ontology functions and the Reactome signaling pathway was performed. A total of 140 proteins/genes were differentially expressed. From cluster analysis, a set of 20 hub genes were significantly modulated: ALB , APOA1 , B2M , C3 , CAT , CLU , CTSD , ENO1 , GSN , HBB , HP , HSPA8 , LTF , LYZ , MMP9 , S100A9 , SERPINA1 , TF , TPI1 , and TXN . Two enriched signaling pathways, glycolysis and gluconeogenesis, and tryptophan signaling pathway involving the hub genes CAT , ENO1 , and TPI1 have been identified. The rest of the hub genes were mainly enriched in the innate immune system and antimicrobial peptides signaling pathways. In summary, hub DEGs and the signaling pathways identified here have elucidated the molecular mechanisms of TMD pathogenesis." @default.
- W4312364680 created "2023-01-04" @default.
- W4312364680 creator A5050237779 @default.
- W4312364680 creator A5070849006 @default.
- W4312364680 creator A5084796147 @default.
- W4312364680 date "2022-01-01" @default.
- W4312364680 modified "2023-10-01" @default.
- W4312364680 title "Identification of crucial salivary proteins/genes and pathways involved in pathogenesis of temporomandibular disorders" @default.
- W4312364680 cites W1591118395 @default.
- W4312364680 cites W1597900755 @default.
- W4312364680 cites W1950035898 @default.
- W4312364680 cites W1963900907 @default.
- W4312364680 cites W1965047634 @default.
- W4312364680 cites W1967922958 @default.
- W4312364680 cites W1980258478 @default.
- W4312364680 cites W1985381306 @default.
- W4312364680 cites W1992089163 @default.
- W4312364680 cites W1994915306 @default.
- W4312364680 cites W2011509273 @default.
- W4312364680 cites W2013513784 @default.
- W4312364680 cites W2016859011 @default.
- W4312364680 cites W2017656054 @default.
- W4312364680 cites W2034400467 @default.
- W4312364680 cites W2037371032 @default.
- W4312364680 cites W2044764337 @default.
- W4312364680 cites W2044893051 @default.
- W4312364680 cites W2052472819 @default.
- W4312364680 cites W2055701861 @default.
- W4312364680 cites W2063487298 @default.
- W4312364680 cites W2064656010 @default.
- W4312364680 cites W2067000150 @default.
- W4312364680 cites W2081030362 @default.
- W4312364680 cites W2083020155 @default.
- W4312364680 cites W2086420062 @default.
- W4312364680 cites W2092866153 @default.
- W4312364680 cites W2100653373 @default.
- W4312364680 cites W2103912979 @default.
- W4312364680 cites W2104743752 @default.
- W4312364680 cites W2109414461 @default.
- W4312364680 cites W2115886971 @default.
- W4312364680 cites W2134031153 @default.
- W4312364680 cites W2134931057 @default.
- W4312364680 cites W2136850043 @default.
- W4312364680 cites W2140207977 @default.
- W4312364680 cites W2143375612 @default.
- W4312364680 cites W2144995521 @default.
- W4312364680 cites W2153339749 @default.
- W4312364680 cites W2156946611 @default.
- W4312364680 cites W2159675211 @default.
- W4312364680 cites W2171030481 @default.
- W4312364680 cites W2178802273 @default.
- W4312364680 cites W2185686228 @default.
- W4312364680 cites W2296911202 @default.
- W4312364680 cites W2336166563 @default.
- W4312364680 cites W2460126719 @default.
- W4312364680 cites W2472988281 @default.
- W4312364680 cites W2521574223 @default.
- W4312364680 cites W2527816216 @default.
- W4312364680 cites W2529539765 @default.
- W4312364680 cites W2548717227 @default.
- W4312364680 cites W2597129987 @default.
- W4312364680 cites W2598909331 @default.
- W4312364680 cites W2604121576 @default.
- W4312364680 cites W2613996502 @default.
- W4312364680 cites W2618183351 @default.
- W4312364680 cites W2735253609 @default.
- W4312364680 cites W2735466792 @default.
- W4312364680 cites W2755877600 @default.
- W4312364680 cites W2760465643 @default.
- W4312364680 cites W2770665224 @default.
- W4312364680 cites W2790620228 @default.
- W4312364680 cites W2795998731 @default.
- W4312364680 cites W2803840850 @default.
- W4312364680 cites W2808305854 @default.
- W4312364680 cites W2826204965 @default.
- W4312364680 cites W2884829889 @default.
- W4312364680 cites W2900569176 @default.
- W4312364680 cites W2900897746 @default.
- W4312364680 cites W2904625821 @default.
- W4312364680 cites W2909432467 @default.
- W4312364680 cites W2919989386 @default.
- W4312364680 cites W2922202816 @default.
- W4312364680 cites W2923472591 @default.
- W4312364680 cites W2950764390 @default.
- W4312364680 cites W2967217029 @default.
- W4312364680 cites W2971013613 @default.
- W4312364680 cites W2977926418 @default.
- W4312364680 cites W2981697829 @default.
- W4312364680 cites W2991645483 @default.
- W4312364680 cites W3001566332 @default.
- W4312364680 cites W3002710359 @default.
- W4312364680 cites W3002893299 @default.
- W4312364680 cites W3003009748 @default.
- W4312364680 cites W3003395974 @default.
- W4312364680 cites W3008728265 @default.
- W4312364680 cites W3012172785 @default.
- W4312364680 cites W3016227087 @default.
- W4312364680 cites W3016445345 @default.