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- W4312366979 abstract "<b>Introduction:</b> Post-COVID-19 Interstitial Lung Disease (ILD) is controversial and need for treatment is unclear. <b>Aim:</b> To investigate the efficacy of methylprednisolone in the treatment of post-COVID-19 ILD. <b>Methods:</b> This multicentre, prospective, randomized controlled clinical trial, included post-COVID ILD patients (ClinicalTrials.gov, NCT:04988282). Post-COVID ILD was defined as the presence of respiratory symptoms, hypoxemia, restrictive lung functions and parenchymal infiltrates on thorax HRCT. 262 post-COVID-19 patients were randomly assigned to one of two arms: the steroid group (n:135) or control group (n:127). For 4 weeks, the steroid group received oral methylprednisolone at a dose of 0.5 mg/kg/day (maximum dose: 48 mg/day). At the end of the study, thorax HRCT, 6-minute walking test and lung function tests were re-evaluated. A good response was defined as a mMRC score of 0, a FVC percentage greater than 80% and absence of hypoxemia at rest or during exercise, greater than 90% resolution of lesions on CT. <b>Results:</b> Good clinical and functional response rates were higher in steroid group compared to the control group (62.9% vs 33.3%; 54.1% vs 33.7%, p<0.001, respectively). Patients with a radiological response in steroid group tend to be higher than control group, but not statistically significant (61.1 % vs 51.1 %, p=0.159). The increase in oxygen saturation, FVC, and 6-minute walking distance were significantly higher in the steroid group compared to the control. Discussion: Systemic corticosteroids improves clinical and functional characteristics and increases oxygen saturation, FVC, and exercise capacity in post-COVID ILD patients compared to the natural course of the disease." @default.
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- W4312366979 date "2022-09-04" @default.
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- W4312366979 title "Methylprednisolone in the treatment of post-COVID-19 Interstitial Lung Disease (STERCOV-ILD)" @default.
- W4312366979 doi "https://doi.org/10.1183/13993003.congress-2022.3404" @default.
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