Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312375112> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4312375112 endingPage "128" @default.
- W4312375112 startingPage "117" @default.
- W4312375112 abstract "Background: The pathophysiology of the inflammatory process reveals intricate signaling which includes the IL-1β, IL-6, and TNFα pathways that could serve as drug targets. Aim: This study determined the effect of the aqueous extract of Gongronema latifolium (AEGL) leaves on the expression of IFNγ, IL-10, CD3, and CD56 in rabbits. Materials and Methods: ELISA tests were performed to determine the effect of the AEGL on the expression of a pro-inflammatory cytokine (IFNγ), an anti-inflammatory cytokine (IL-10), and CD3 and CD56 cell surface markers in rabbits. Twenty cross-bred male rabbits with an average weight range of 1.0 - 1.5 kg were selected. The rabbits were separated into four groups of four rabbits each treated as follows: Grp1 is the untreated control; Grp2 is the treated control; and Grp3, Grp4, and Grp5 were treated with 200, 400, and 600 mg/kg of AEGL respectively for 28 days. Results: The AEGL showed its greatest inhibitory effect in Group 4 on IL-10 (118.5 pg/ml), and IFNγ (332 pg/ml) on days 14 and 21 respectively. AEGL also showed the highest inhibition of CD3 expression on days 14 and 21 (0 pg/ml) in Group 3; and CD56 expression on day 21 (630.5 pg/ml) in Group 4. Conclusion: AEGL showed exhibited strong T cell mediated anti- inflammatory, and immunomodulatory activity in test rabbits within the 28-day period which can be confirmed by cell based assays. Specifically at 400 mg/kg, AEGL exhibited the greatest anti-inflammatory activity which is suggestive of its maximum effective dose." @default.
- W4312375112 created "2023-01-04" @default.
- W4312375112 creator A5026839722 @default.
- W4312375112 creator A5033430558 @default.
- W4312375112 creator A5047006880 @default.
- W4312375112 creator A5056208585 @default.
- W4312375112 creator A5066325733 @default.
- W4312375112 creator A5069801974 @default.
- W4312375112 creator A5082562043 @default.
- W4312375112 creator A5085664436 @default.
- W4312375112 date "2022-01-01" @default.
- W4312375112 modified "2023-09-30" @default.
- W4312375112 title "Aqueous Leaves Extract of <i>Gongronema latifolium</i> (Benth) Downregulates the Expression of IFN-γ, IL-10 and Cell Surface Markers in Rabbits" @default.
- W4312375112 cites W1548811205 @default.
- W4312375112 cites W1952821838 @default.
- W4312375112 cites W1978122726 @default.
- W4312375112 cites W1989233395 @default.
- W4312375112 cites W2015448485 @default.
- W4312375112 cites W2017749666 @default.
- W4312375112 cites W2022230519 @default.
- W4312375112 cites W2027164200 @default.
- W4312375112 cites W2053288382 @default.
- W4312375112 cites W2061529144 @default.
- W4312375112 cites W2096428863 @default.
- W4312375112 cites W2105202353 @default.
- W4312375112 cites W2108318095 @default.
- W4312375112 cites W2113633144 @default.
- W4312375112 cites W2118120813 @default.
- W4312375112 cites W2346659293 @default.
- W4312375112 cites W2592326108 @default.
- W4312375112 cites W2733704940 @default.
- W4312375112 cites W2774047488 @default.
- W4312375112 cites W2795760871 @default.
- W4312375112 cites W2888218122 @default.
- W4312375112 cites W2892329002 @default.
- W4312375112 cites W2899408092 @default.
- W4312375112 cites W2902460584 @default.
- W4312375112 cites W2977578243 @default.
- W4312375112 cites W2984902823 @default.
- W4312375112 cites W3043704009 @default.
- W4312375112 cites W3086635794 @default.
- W4312375112 cites W4205378836 @default.
- W4312375112 doi "https://doi.org/10.4236/ojmm.2022.124011" @default.
- W4312375112 hasPublicationYear "2022" @default.
- W4312375112 type Work @default.
- W4312375112 citedByCount "0" @default.
- W4312375112 crossrefType "journal-article" @default.
- W4312375112 hasAuthorship W4312375112A5026839722 @default.
- W4312375112 hasAuthorship W4312375112A5033430558 @default.
- W4312375112 hasAuthorship W4312375112A5047006880 @default.
- W4312375112 hasAuthorship W4312375112A5056208585 @default.
- W4312375112 hasAuthorship W4312375112A5066325733 @default.
- W4312375112 hasAuthorship W4312375112A5069801974 @default.
- W4312375112 hasAuthorship W4312375112A5082562043 @default.
- W4312375112 hasAuthorship W4312375112A5085664436 @default.
- W4312375112 hasBestOaLocation W43123751121 @default.
- W4312375112 hasConcept C11988809 @default.
- W4312375112 hasConcept C126322002 @default.
- W4312375112 hasConcept C134018914 @default.
- W4312375112 hasConcept C1491633281 @default.
- W4312375112 hasConcept C185592680 @default.
- W4312375112 hasConcept C203014093 @default.
- W4312375112 hasConcept C2776914184 @default.
- W4312375112 hasConcept C2778690821 @default.
- W4312375112 hasConcept C55493867 @default.
- W4312375112 hasConcept C71924100 @default.
- W4312375112 hasConcept C86803240 @default.
- W4312375112 hasConcept C98274493 @default.
- W4312375112 hasConceptScore W4312375112C11988809 @default.
- W4312375112 hasConceptScore W4312375112C126322002 @default.
- W4312375112 hasConceptScore W4312375112C134018914 @default.
- W4312375112 hasConceptScore W4312375112C1491633281 @default.
- W4312375112 hasConceptScore W4312375112C185592680 @default.
- W4312375112 hasConceptScore W4312375112C203014093 @default.
- W4312375112 hasConceptScore W4312375112C2776914184 @default.
- W4312375112 hasConceptScore W4312375112C2778690821 @default.
- W4312375112 hasConceptScore W4312375112C55493867 @default.
- W4312375112 hasConceptScore W4312375112C71924100 @default.
- W4312375112 hasConceptScore W4312375112C86803240 @default.
- W4312375112 hasConceptScore W4312375112C98274493 @default.
- W4312375112 hasIssue "04" @default.
- W4312375112 hasLocation W43123751121 @default.
- W4312375112 hasOpenAccess W4312375112 @default.
- W4312375112 hasPrimaryLocation W43123751121 @default.
- W4312375112 hasRelatedWork W2034985166 @default.
- W4312375112 hasRelatedWork W2041570680 @default.
- W4312375112 hasRelatedWork W2093444646 @default.
- W4312375112 hasRelatedWork W2273452210 @default.
- W4312375112 hasRelatedWork W2315342627 @default.
- W4312375112 hasRelatedWork W2317914672 @default.
- W4312375112 hasRelatedWork W2748952813 @default.
- W4312375112 hasRelatedWork W2899084033 @default.
- W4312375112 hasRelatedWork W2948395568 @default.
- W4312375112 hasRelatedWork W4254218321 @default.
- W4312375112 hasVolume "12" @default.
- W4312375112 isParatext "false" @default.
- W4312375112 isRetracted "false" @default.
- W4312375112 workType "article" @default.