FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312378856> ?p ?o ?g. }

• W4312378856 endingPage "S243" @default.
• W4312378856 startingPage "S243" @default.
• W4312378856 abstract "Introduction: Although antibiotic treatment is one of the cornerstones of management of (suspected) infected necrotizing pancreatitis, indication, timing, duration and the type of antimicrobial regimes is still debated and vary. Methods: We performed a post-hoc analysis of a prospective multicenter cohort of 449 patients with necrotizing pancreatitis treated in 15 Dutch hospitals (2010 to 2019). Results on microbiological cultures and antimicrobial therapy were analysed. Results: Antimicrobial therapy was started in 369 (82%) of all patients with necrotizing pancreatitis, after a median of 5 (P25-P75: 1 – 14) days after admission. In 224/369 (70%) patients, the first antimicrobial therapy was started without a confirmed infection. Although carbapenems, specifically meropenem (n=75, 29%), were most frequently used as empirical antimicrobial therapy, Enterococcus faecium (which is intrinsically resistant to carbapenems) was frequently (24%) cultured in infected pancreatic necrosis. Multidrug-resistant bacteria were rare in the initial culture sample (2%), but increased to 14% in subsequent cultures. Empirical antimicrobial therapy started before the positive culture was appropriate in 64/128 patients (50%) with a positive pancreatic culture. In 87% of the patients with a culture that contained (partial) resistant bacteria the antibiotic regime was adjusted appropriately. Conclusion: In daily clinical practice, antimicrobial therapy are started early during necrotizing pancreatitis, mostly without a confirmed infection. E. faecium was the most frequently cultured microbe. Based on bacterial resistance and yeast involvement, empirically administered antibiotics often turn out inappropriate. Optimization of antimicrobial therapy has the potential to reduce unnecessary antibiotic use while improving clinical outcomes of patients with (infected) necrotizing pancreatitis." @default.
• W4312378856 created "2023-01-04" @default.
• W4312378856 creator A5009834418 @default.
• W4312378856 creator A5013100335 @default.
• W4312378856 creator A5014607933 @default.
• W4312378856 creator A5019687072 @default.
• W4312378856 creator A5023235245 @default.
• W4312378856 creator A5024699380 @default.
• W4312378856 creator A5028122107 @default.
• W4312378856 creator A5029730071 @default.
• W4312378856 creator A5030658284 @default.
• W4312378856 creator A5031476012 @default.
• W4312378856 creator A5032468962 @default.
• W4312378856 creator A5033279901 @default.
• W4312378856 creator A5033408512 @default.
• W4312378856 creator A5034721052 @default.
• W4312378856 creator A5034801254 @default.
• W4312378856 creator A5035626190 @default.
• W4312378856 creator A5035888657 @default.
• W4312378856 creator A5036373748 @default.
• W4312378856 creator A5040212571 @default.
• W4312378856 creator A5041561606 @default.
• W4312378856 creator A5045632993 @default.
• W4312378856 creator A5047421217 @default.
• W4312378856 creator A5051827787 @default.
• W4312378856 creator A5060176696 @default.
• W4312378856 creator A5084402300 @default.
• W4312378856 date "2022-01-01" @default.
• W4312378856 modified "2023-10-14" @default.
• W4312378856 title "Microbiology and Antimicrobial Therapy in (Infected) Necrotizing Pancreatitis: A Prospective Observational Cohort Study" @default.
• W4312378856 doi "https://doi.org/10.1016/j.hpb.2022.05.508" @default.
• W4312378856 hasPublicationYear "2022" @default.
• W4312378856 type Work @default.
• W4312378856 citedByCount "0" @default.
• W4312378856 crossrefType "journal-article" @default.
• W4312378856 hasAuthorship W4312378856A5009834418 @default.
• W4312378856 hasAuthorship W4312378856A5013100335 @default.
• W4312378856 hasAuthorship W4312378856A5014607933 @default.
• W4312378856 hasAuthorship W4312378856A5019687072 @default.
• W4312378856 hasAuthorship W4312378856A5023235245 @default.
• W4312378856 hasAuthorship W4312378856A5024699380 @default.
• W4312378856 hasAuthorship W4312378856A5028122107 @default.
• W4312378856 hasAuthorship W4312378856A5029730071 @default.
• W4312378856 hasAuthorship W4312378856A5030658284 @default.
• W4312378856 hasAuthorship W4312378856A5031476012 @default.
• W4312378856 hasAuthorship W4312378856A5032468962 @default.
• W4312378856 hasAuthorship W4312378856A5033279901 @default.
• W4312378856 hasAuthorship W4312378856A5033408512 @default.
• W4312378856 hasAuthorship W4312378856A5034721052 @default.
• W4312378856 hasAuthorship W4312378856A5034801254 @default.
• W4312378856 hasAuthorship W4312378856A5035626190 @default.
• W4312378856 hasAuthorship W4312378856A5035888657 @default.
• W4312378856 hasAuthorship W4312378856A5036373748 @default.
• W4312378856 hasAuthorship W4312378856A5040212571 @default.
• W4312378856 hasAuthorship W4312378856A5041561606 @default.
• W4312378856 hasAuthorship W4312378856A5045632993 @default.
• W4312378856 hasAuthorship W4312378856A5047421217 @default.
• W4312378856 hasAuthorship W4312378856A5051827787 @default.
• W4312378856 hasAuthorship W4312378856A5060176696 @default.
• W4312378856 hasAuthorship W4312378856A5084402300 @default.
• W4312378856 hasBestOaLocation W43123788561 @default.
• W4312378856 hasConcept C126322002 @default.
• W4312378856 hasConcept C141071460 @default.
• W4312378856 hasConcept C177713679 @default.
• W4312378856 hasConcept C188816634 @default.
• W4312378856 hasConcept C2775967933 @default.
• W4312378856 hasConcept C2777677444 @default.
• W4312378856 hasConcept C2779375183 @default.
• W4312378856 hasConcept C4937899 @default.
• W4312378856 hasConcept C501593827 @default.
• W4312378856 hasConcept C71924100 @default.
• W4312378856 hasConcept C86803240 @default.
• W4312378856 hasConcept C89423630 @default.
• W4312378856 hasConcept C94665300 @default.
• W4312378856 hasConceptScore W4312378856C126322002 @default.
• W4312378856 hasConceptScore W4312378856C141071460 @default.
• W4312378856 hasConceptScore W4312378856C177713679 @default.
• W4312378856 hasConceptScore W4312378856C188816634 @default.
• W4312378856 hasConceptScore W4312378856C2775967933 @default.
• W4312378856 hasConceptScore W4312378856C2777677444 @default.
• W4312378856 hasConceptScore W4312378856C2779375183 @default.
• W4312378856 hasConceptScore W4312378856C4937899 @default.
• W4312378856 hasConceptScore W4312378856C501593827 @default.
• W4312378856 hasConceptScore W4312378856C71924100 @default.
• W4312378856 hasConceptScore W4312378856C86803240 @default.
• W4312378856 hasConceptScore W4312378856C89423630 @default.
• W4312378856 hasConceptScore W4312378856C94665300 @default.
• W4312378856 hasLocation W43123788561 @default.
• W4312378856 hasOpenAccess W4312378856 @default.
• W4312378856 hasPrimaryLocation W43123788561 @default.
• W4312378856 hasRelatedWork W2008878688 @default.
• W4312378856 hasRelatedWork W2144124556 @default.
• W4312378856 hasRelatedWork W2163337866 @default.
• W4312378856 hasRelatedWork W2318509744 @default.
• W4312378856 hasRelatedWork W2412979414 @default.
• W4312378856 hasRelatedWork W2964912953 @default.
• W4312378856 hasRelatedWork W3128949511 @default.
• W4312378856 hasRelatedWork W3135108420 @default.

• next