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• W4312396196 abstract "Multidrug-resistant (MDR) pathogens are becoming a serious global threat in the treatment of burn wounds, surgical site infections, and chronic wounds, driving the need for the development of new sterilizing techniques to disinfect the wounds. To address this, a novel and flexible microplasma discharge device (MDD) was fabricated using the additive print manufacturing process for the eradication of pathogens such as <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Candida albicans</i> , an opportunistic pathogenic yeast (fungus), and three bacterial species from the ESKAPE <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>(Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter spp)</i> group including <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Enterococcus faecium, Klebsiella pneumoniae</i> , and <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Acinetobacter baumannii</i> using ambient air as the sterilization agent. To fabricate the MDD, silver ink (Ag) was deposited on flexible polyethylene terephthalate (PET) films in a circular design consisting of a honeycomb pattern using a screen-printing process to fabricate the top and bottom electrodes. An average thickness and a roughness of <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$sim 9$ </tex-math></inline-formula> and <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$sim 2~mu text{m}$ </tex-math></inline-formula> were measured for the screen-printed silver layer, respectively. Then, the MDD was assembled by attaching the top and bottom electrodes using a two-sided Kapton tape (dielectric layer). The antifungal and antibacterial efficacies of the MDD were investigated by varying applied voltage (6, 8, and 10 V). The antifungal and antibacterial efficacies of 100% were achieved at an applied voltage of 10 V for a treatment time of 1 min. In addition, the surface temperature of the MDD was measured from 25 °C to 68 °C at the applied voltages ranging from 6 to 10 V, respectively. The MDD performs similarly both in flat and bent conditions (on surfaces with 25 and 50 mm radius of curvatures), indicating that it is flexible. This flexible and printed MDD can be potentially applied as a wearable bandage in hospitals to sterilize burn wound injuries, which mostly contains <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>C. albicans</i> and ESKAPE pathogens, and accelerate the wound healing process." @default.
• W4312396196 created "2023-01-04" @default.
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• W4312396196 date "2023-03-01" @default.
• W4312396196 modified "2023-09-29" @default.
• W4312396196 title "Flexible Microplasma Discharge Device for Treating Multidrug-Resistant Fungal and Bacterial Infections" @default.
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• W4312396196 doi "https://doi.org/10.1109/jflex.2022.3223889" @default.
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