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- W4312452330 abstract "Isoniazid is an antimicrobial used for the treatment or prevention of tuberculosis. It is available for both oral and parenteral administration. It is rapidly absorbed and undergoes metabolism through the cytochrome P450 system by N-acetylation. Genetic variations in the human population alter the rate of acetylation, thus causing variation in the concentration and half-life of the drug. Isoniazid causes toxicity by altering the metabolism of pyridoxine and can cause peripheral neuropathy, seizures, hepatotoxicity, and metabolic acidosis. Supportive care in addition to pyridoxine administration should be implemented if these clinical manifestations occur." @default.
- W4312452330 created "2023-01-04" @default.
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- W4312452330 date "2022-01-01" @default.
- W4312452330 modified "2023-09-24" @default.
- W4312452330 title "Isoniazid" @default.
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- W4312452330 doi "https://doi.org/10.1016/b978-0-12-824315-2.00121-4" @default.
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