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- W4312456027 abstract "Immune complex-mediated MPGN is a disease of young adults and children who frequently present with hematuria, proteinuria, nephrotic or nephritic syndrome. Progression to end-stage renal disease can be seen in 40% of patients over a period of 10 years. The renal biopsy would reveal that the glomeruli are enlarged with accentuated lobular pattern and look pale with a global increase of glomerular cellularity caused by endocapillary hyperplasia and mesangial cells proliferation as well as infiltration of polymorphonuclear inflammatory cells in some cases. The glomerular capillary basement membrane shows reduplication (tram track/double contour). On immunofluorescence immunoglobulins along with complement deposits are seen in subendothelial and mesangial compartments. On electron microscopy, patients have subendothelial and mesangial electron-dense deposits with variable subepithelial and intramembranous deposits. Thickening and double contours of glomerular capillary basement membrane are seen. It is one of the common causes of recurrent glomerulonephritis (27–65%) after renal transplantation." @default.
- W4312456027 created "2023-01-04" @default.
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- W4312456027 date "2022-01-01" @default.
- W4312456027 modified "2023-09-30" @default.
- W4312456027 title "Immune Complex-Mediated MPGN (Previously MPGN Type I)" @default.
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- W4312456027 doi "https://doi.org/10.1007/978-981-19-1430-0_5" @default.
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