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- W4312470525 abstract "The potential of immunotherapy as a treatment method for cancer is obvious based on the significant clinical response of a significant number of patients, mainly to chimeric antigen receptor-expressing pericyte transfer using transgenic autologous T cells. Nevertheless, the vast majority of malignant solid tumors do not respond specifically to CAR-T cell injections such as breast, colon and lung cancers. Suboptimal outcomes have been linked to lower expansion. They are also related to the durability of adoptively transferred CAR-T cells, antigen-negative relapses, and impairment by an immunosuppressive tumor microenvironment in a series of clinical trials. The current status of CAR-T cell therapy of solid cancers is discussed. At the same time, this paper also discusses the barriers and how to overcome these obstacles so that CAR-T immunotherapy can be one of the treatment methods for malignant solid tumors." @default.
- W4312470525 created "2023-01-04" @default.
- W4312470525 creator A5027605982 @default.
- W4312470525 date "2022-01-01" @default.
- W4312470525 modified "2023-10-15" @default.
- W4312470525 title "Current status of CAR-T cells in the treatment of malignant solid tumors" @default.
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- W4312470525 doi "https://doi.org/10.1063/5.0111898" @default.
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