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• W4312476861 abstract "<b>Background:</b> Innovative information techniques are increasingly used to perform federated analyses in real-world studies. Whether these techniques are suitable for harmonizing patient data from non-standardized registries and evaluating treatment outcomes needs further evidence. <b>Aim:</b> To standardize patient-level registry data from SHARP (Severe Heterogeneous Asthma Registry Patient-centred) and evaluate the effectiveness of mepolizumab on frequent (≥2/yr) exacerbations in patients with severe asthma. <b>Methods:</b> We standardized data from 5,871 adults with severe asthma in 10 European countries using the OMOP Common Data Model (www.ohdsi.org). Patients who had taken mepolizumab ≥1 yr (2016-2021) and had exacerbation data available were included. Changes in odds of ≥2 exacerbations/yr were evaluated. <b>Results:</b> Of 2,109 patients who initiated mepolizumab 563 met inclusion criteria. Analysis showed a reduction of having ≥2 (vs 0-1) annual exacerbations after 1 yr mepolizumab therapy: OR (95%CI) 0.18 (0.13-0.25)[N=369] pre and 0.08 (0.05-0.13)[N=194] during the COVID-19 pandemic (Fig). <b>Conclusions:</b> By harmonizing non-standardized, patient-level registry data and applying federated analysis we demonstrated that mepolizumab reduced asthma exacerbations, consistent with current knowledge. This paves the way for future pan-European real-world severe asthma studies using patient-level data in a privacy-proof way. Supported by GSK (212821)." @default.
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• W4312476861 date "2022-09-04" @default.
• W4312476861 modified "2023-09-30" @default.
• W4312476861 title "Mepolizumab effectiveness in severe asthma supported by federated analysis of European SHARP data" @default.
• W4312476861 doi "https://doi.org/10.1183/13993003.congress-2022.4340" @default.
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