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- W4312492042 abstract "Hyperhomocysteinemia is an independent thrombotic risk factor in patients with cardiovascular disease and has several mechanisms of procoagulant action. The mechanisms of development hyperhomocysteinemia and COPD have similar predictors, such as smoking, inflammation, and oxidative stress. <b>Purpose:</b> Determination of the significance of homocysteine as a marker of high thrombophilic risk in patients with COPD. <b>Materials and methods:</b> The study included 92 patients diagnosed with COPD, who were divided into 2 groups according to the presence of thrombosis in history (patients with/without). The levels of homocysteine were determined by ELISA. <b>Results:</b> When determining the level of homocysteine in the group of patients without a history of thrombosis(n=60), it was 17.9±1.37 µmol/l, whereas in the group with thrombosis (n=32) 26.6±2.4 µmol/l. When determining the degree of increase in homocysteine in the group with thrombosis, a high-risk level of homocysteine of 30 µmol/l was found in 33.3% of patients, while in the group without thrombosis this figure was only 4.1% (p<0.001). <b>Conclusions:</b> Homocysteine is a contender for the role of the main predictor of thrombophilia in COPD. In order to prevent thrombophilia in COPD patients, strategies to control hyperhomocysteinemia should be developed." @default.
- W4312492042 created "2023-01-05" @default.
- W4312492042 creator A5025955392 @default.
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- W4312492042 date "2022-09-04" @default.
- W4312492042 modified "2023-09-30" @default.
- W4312492042 title "Hyperhomocysteinemia as the main thrombophilic risk marker in COPD" @default.
- W4312492042 doi "https://doi.org/10.1183/13993003.congress-2022.1877" @default.
- W4312492042 hasPublicationYear "2022" @default.
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