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- W4312510708 abstract "The role of carotenoids on reducing vitamin A deficiency and cardiovascular and age-related degenerative diseases has been addressed in the last three decades. Likewise, anticancer activity, cell cycle regulation, enhanced gap junctional communication, inhibition of malignant transformation, and apoptosis induction of carotenoids are elucidated by superior antioxidant activities. Focus on oxidative stress physiologyOxidative stress physiology and chemistry of carotenoids on the cancer reduction incidence is poorly understood and needs to be explained systematically. To this end, the nature and chemistry of interaction related to cellular uptake, disposition, pro-oxidant/oxidation reaction, and apoptosis signaling of distinct carotenoids elucidating anticancer potential is most paramount. Additionally, the stability, biotransformation, and formation of carotenoid oxidative cleavage products/metabolites and their structural properties are yet to be established and, therefore, need a good platform for the study. Therefore, this chapter has been tailored to emphasize and construe the structure and properties of carotenoids in relation to oxidative stress physiology of cancer cells. In this context, speculations of the carotenoid mechanism of action through chemical biology approach facilitate greater insights in tandem with synthetic chemistry." @default.
- W4312510708 created "2023-01-05" @default.
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- W4312510708 date "2022-01-01" @default.
- W4312510708 modified "2023-09-23" @default.
- W4312510708 title "Free Radical Chemistry of Carotenoids and Oxidative Stress Physiology of Cancer" @default.
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- W4312510708 doi "https://doi.org/10.1007/978-981-16-5422-0_262" @default.
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