Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312517972> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4312517972 endingPage "654" @default.
- W4312517972 startingPage "639" @default.
- W4312517972 abstract "This study analysed the interactions between the chemical structures and antimicrobial activities of various functional groups containing organic compounds. The spectral methods confirmed the structure of these compounds after efficient synthesis was carried out. Two Gram-positive and two Gram-negative bacteria were tested for in vitro antibacterial activity of the synthesised compounds. For antifungal activity, three fungal strains were tested. Compound 5n showed a potent inhibitory effects against E. coli and P. aeruginosa with MIC values of 12.5 µg/ml and 6.25 µg/ml, respectively (Glide Docking score: -9.190). S. aureus and S. pyogenus were both positively affected by compound 5i with MIC values of 12.5 µg/ml and 25 µg/ml, respectively (Glide Docking score: -9.111). Based on the results, compounds 5a and 5f have excellent activity against C. albicans with MIC values of 200 µg/ml. Molecular docking study against microbial peptide deformylase could provide insight into the binding affinity and orientation of the active site. A very significant correlation was obtained between the in silico binding affinity data with an average Glide docking score of -8.412 and Glide binding energy: -43.074 kcal/mol. Compound 5n produced a relatively higher binding affinity (Glide dock score: -9.190 and Glide binding energy: -51.226 kcal/mol) which was also translated in its higher antimicrobial activity." @default.
- W4312517972 created "2023-01-05" @default.
- W4312517972 creator A5043608863 @default.
- W4312517972 creator A5062524958 @default.
- W4312517972 creator A5072452840 @default.
- W4312517972 creator A5083450321 @default.
- W4312517972 date "2022-09-03" @default.
- W4312517972 modified "2023-09-26" @default.
- W4312517972 title "Design, Synthesis, Antimicrobial Activity and Molecular docking Studies of Pyridine Based Thiazolidine-4-one and Its 5-Arylidene Derivatives" @default.
- W4312517972 cites W1509733399 @default.
- W4312517972 cites W1985588649 @default.
- W4312517972 cites W1987810048 @default.
- W4312517972 cites W2009423060 @default.
- W4312517972 cites W2037761710 @default.
- W4312517972 cites W2050928252 @default.
- W4312517972 cites W2084904678 @default.
- W4312517972 cites W2097233276 @default.
- W4312517972 cites W2102377211 @default.
- W4312517972 cites W2168879804 @default.
- W4312517972 cites W2895587415 @default.
- W4312517972 cites W2914770362 @default.
- W4312517972 cites W3011366455 @default.
- W4312517972 cites W3013073252 @default.
- W4312517972 cites W3016762617 @default.
- W4312517972 cites W3043812607 @default.
- W4312517972 cites W3046364878 @default.
- W4312517972 cites W3097070695 @default.
- W4312517972 cites W3120090335 @default.
- W4312517972 cites W3125053024 @default.
- W4312517972 cites W3194063207 @default.
- W4312517972 cites W3194188670 @default.
- W4312517972 cites W4200022284 @default.
- W4312517972 cites W4206677002 @default.
- W4312517972 cites W4225619826 @default.
- W4312517972 cites W4280537261 @default.
- W4312517972 cites W4281959671 @default.
- W4312517972 doi "https://doi.org/10.1080/22297928.2022.2148558" @default.
- W4312517972 hasPublicationYear "2022" @default.
- W4312517972 type Work @default.
- W4312517972 citedByCount "0" @default.
- W4312517972 crossrefType "journal-article" @default.
- W4312517972 hasAuthorship W4312517972A5043608863 @default.
- W4312517972 hasAuthorship W4312517972A5062524958 @default.
- W4312517972 hasAuthorship W4312517972A5072452840 @default.
- W4312517972 hasAuthorship W4312517972A5083450321 @default.
- W4312517972 hasConcept C176947019 @default.
- W4312517972 hasConcept C178790620 @default.
- W4312517972 hasConcept C185592680 @default.
- W4312517972 hasConcept C21951064 @default.
- W4312517972 hasConcept C2780104969 @default.
- W4312517972 hasConcept C2780917455 @default.
- W4312517972 hasConcept C41685203 @default.
- W4312517972 hasConcept C42972112 @default.
- W4312517972 hasConcept C4937899 @default.
- W4312517972 hasConcept C523546767 @default.
- W4312517972 hasConcept C54355233 @default.
- W4312517972 hasConcept C71240020 @default.
- W4312517972 hasConcept C71924100 @default.
- W4312517972 hasConcept C86803240 @default.
- W4312517972 hasConcept C89423630 @default.
- W4312517972 hasConceptScore W4312517972C176947019 @default.
- W4312517972 hasConceptScore W4312517972C178790620 @default.
- W4312517972 hasConceptScore W4312517972C185592680 @default.
- W4312517972 hasConceptScore W4312517972C21951064 @default.
- W4312517972 hasConceptScore W4312517972C2780104969 @default.
- W4312517972 hasConceptScore W4312517972C2780917455 @default.
- W4312517972 hasConceptScore W4312517972C41685203 @default.
- W4312517972 hasConceptScore W4312517972C42972112 @default.
- W4312517972 hasConceptScore W4312517972C4937899 @default.
- W4312517972 hasConceptScore W4312517972C523546767 @default.
- W4312517972 hasConceptScore W4312517972C54355233 @default.
- W4312517972 hasConceptScore W4312517972C71240020 @default.
- W4312517972 hasConceptScore W4312517972C71924100 @default.
- W4312517972 hasConceptScore W4312517972C86803240 @default.
- W4312517972 hasConceptScore W4312517972C89423630 @default.
- W4312517972 hasIssue "5" @default.
- W4312517972 hasLocation W43125179721 @default.
- W4312517972 hasOpenAccess W4312517972 @default.
- W4312517972 hasPrimaryLocation W43125179721 @default.
- W4312517972 hasRelatedWork W2263307492 @default.
- W4312517972 hasRelatedWork W2271281509 @default.
- W4312517972 hasRelatedWork W2372741438 @default.
- W4312517972 hasRelatedWork W2418982244 @default.
- W4312517972 hasRelatedWork W2907260318 @default.
- W4312517972 hasRelatedWork W4288453051 @default.
- W4312517972 hasRelatedWork W4310522864 @default.
- W4312517972 hasRelatedWork W2002374332 @default.
- W4312517972 hasRelatedWork W2187025896 @default.
- W4312517972 hasRelatedWork W2305699482 @default.
- W4312517972 hasVolume "12" @default.
- W4312517972 isParatext "false" @default.
- W4312517972 isRetracted "false" @default.
- W4312517972 workType "article" @default.