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- W4312552906 abstract "<b>Background:</b> - No reliable reference standard exists to diagnose bacterial lower respiratory tract infection (LRTI), posing a challenge for diagnosis and treatment. We prospectively explored the association between clinical presentation, microbiology and a blood-based 29 mRNA host-response test in patients with suspicion of LRTI. <b>Methods:</b> - The PAX study is a prospective, single-center observational study. An interim analysis of 145 cases with suspected LRTI undergoing bronchoscopy with bronchoalveolar lavage (BAL) is presented. Blood was analyzed for 29 mRNA host-response using InSep™ (Inflammatix, California, USA). Strict definitions for very likely, possible, unlikely and very unlikely bacterial infection were provided to the adjudicators. <b>Results:</b> - The patients’ average age was 66±15 years with 52% immunocompromised. Clinical presentation but not microbiological methods was significantly differentiated across the categories assessing probability of bacterial infection by mRNA signatures (p=0.008 and p=0.219, respectively). Using conventional methods as a reference standard, the mRNA host-response score showed 40% sensitivity and 70% specificity, compared to clinical presentation that showed 78% sensitivity and 54% specificity for bacterial infection. <b>Conclusion:</b> - There is an association between clinical presentation and an inflammatory host-response test for bacterial infection. Clinical presentation, microbiology and mRNA host-response may be complementary aspects to inform about infection likelihood. The analysis of the entire cohort will allow for robust inferences." @default.
- W4312552906 created "2023-01-05" @default.
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- W4312552906 date "2022-09-04" @default.
- W4312552906 modified "2023-10-18" @default.
- W4312552906 title "Host transcriptomic signature for infection in patients with suspicion of LRTI undergoing bronchoscopy" @default.
- W4312552906 doi "https://doi.org/10.1183/13993003.congress-2022.3036" @default.
- W4312552906 hasPublicationYear "2022" @default.
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