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- W4312556211 abstract "Abstract We studied the effect of beryllium fluoride on murine peritoneal macrophages and determined its effects on signal transduction and genetic regulation. At low concentration (1–5 nM), BeF2 caused an approximate twofold increase in [3H]thymidine uptake and cell number, but above 5 nM, it showed cytotoxic effects. BeF2 increased cellular inositol (1,4,5)trisphosphate (IP3) and [Ca2+]i about twofold. The rise in [Ca2+]i occurred consequent to release from IP3-sensitive Ca2+ stores and from influx, mainly via L-type channels. A significant increase in the levels of MEK1, ERK1, p38 MAPK, and JNK phosphorylation was observed in BeF2-exposed macrophages. The levels of NF-κB and CREB transcription factors and the proto-oncogenesc-fos and c-myc were also elevated significantly. Intracellular Ca2+ chelation blocked the effect of BeF2. We conclude that BeF2 at low concentration exerts its mitogenic effects in peritoneal macrophages by elevating [Ca2+]i, which triggers the activation of p21ras-dependent MAPK signaling cascades." @default.
- W4312556211 created "2023-01-05" @default.
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- W4312556211 date "2002-03-01" @default.
- W4312556211 modified "2023-10-16" @default.
- W4312556211 title "Beryllium fluoride-induced cell proliferation: a process requiring P21ras-dependent activated signal transduction and NF-κB-dependent gene regulation" @default.
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- W4312556211 doi "https://doi.org/10.1189/jlb.71.3.487" @default.
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