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- W4312559973 abstract "<b>Introduction:</b> Olfactory loss is prevalent in SARS-CoV-2 infected patients. Some therapies have been tested to help patients, but both time to symptom recovery and prevalence of full recovery are unknown, and prospective studies testing any method of therapy are rare. <b>Objectives:</b> Compare olfactory training effectivity in improving smell sense in COVID-19 patients with olfactory loss after acute disease. <b>Methods:</b> subjects that had olfactory loss during confirmed COVID-19 performed Connecticut Chemosensory Clinical Research Center olfactory test. Those who presented with some grade of olfactory loss were invited to participate this trial, in which they were randomized in 2 groups (olfactory training versus a control group with olfactory training without smell sensation). Patients were evaluated monthly until full olfactory recovery or until 6 months of follow-up. <b>Results:</b> among 182 individuals, 149 presented with abnormal olfactory test. 123 patients finished the study (treatment: n=68; control: n=55). Both groups showed olfactory improvement along the follow-up period with significant statistical difference until the second reevaluation (1st-2nd test: p<.001; 2nd-3rd test: p<.001; 3rd-4th test: p=.08; 4th-5th test: p=1; 5th-6th test: p=1; 6th-7th test: p=1). Olfactory test was significant better at control group at the beginning (p=.001) and persisted until the second reevaluation (p=.004 and p=.009, respectively), in which treatment group had similar test results (p>.05). <b>Conclusions:</b> Olfactory training demonstrated good results as treatment modality after COVID-19 smell loss, with significant improvement after 70 days of therapy. Sponsored by FAPESP #2020/09378-0 UNICOVIDS group" @default.
- W4312559973 created "2023-01-05" @default.
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- W4312559973 date "2022-09-04" @default.
- W4312559973 modified "2023-10-16" @default.
- W4312559973 title "Olfactory rehabilitation in non-severe COVID-19 patients: a randomized double-blinded clinical trial" @default.
- W4312559973 doi "https://doi.org/10.1183/13993003.congress-2022.3327" @default.
- W4312559973 hasPublicationYear "2022" @default.
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