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• W4312563344 startingPage "205" @default.
• W4312563344 abstract "Congestive heart failure (CHF) is the leading cause of morbidity and mortality in the elderly worldwide. Although many biomarkers associated with in heart failure, these are generally prognostic and identify patients with moderate and severe disease. Unfortunately, the role of biomarkers in decision making for early and advanced heart failure remains largely unexplored. Previous studies suggest the natriuretic peptides have the potential to improve the diagnosis of heart failure, but they still have significant limitations related to cut-off values. Although some promising cardiac biomarkers have emerged, comprehensive data from large cohort studies is lacking. The utility of multiple biomarkers that reflect various pathophysiologic pathways are increasingly being explored in heart failure risk stratification and to diagnose disease conditions promptly and accurately. MicroRNAs serve as mediators and/or regulators of renin-angiotensin-induced cardiac remodeling by directly targeting enzymes, receptors and signaling molecules. The role of miRNA in HF diagnosis is a promising area of research and further exploration may offer both diagnostic and prognostic applications and phenotype-specific targets. In this review, we provide insight into the classification of different biochemical and molecular markers associated with CHF, examine clinical usefulness in CHF and highlight the most clinically relevant." @default.
• W4312563344 created "2023-01-05" @default.
• W4312563344 creator A5004305359 @default.
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• W4312563344 creator A5021571710 @default.
• W4312563344 creator A5057285080 @default.
• W4312563344 creator A5067717843 @default.
• W4312563344 date "2023-01-01" @default.
• W4312563344 modified "2023-09-27" @default.
• W4312563344 title "Advances in congestive heart failure biomarkers" @default.
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