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- W4312581711 abstract "<b>Background:</b> Increasing evidence demonstrates excess long-term mortality among tuberculosis (TB) patients despite successful treatment, but long-term mortality has not been compared against other common infections. <b>Aim:</b> To determine long-term mortality of TB patients up to 20 years post diagnosis compared to patients diagnosed with influenza and Salmonella infection. <b>Methods:</b> Between 1st January 2000 and 31st December 2015, all notified TB cases in New South Wales, Australia were identified and matched by age, gender and year of infection to patients with documented influenza or salmonella infection. Cases were then linked to the Australian mortality database to assess date and cause of death registered to 31 December 2021. The standardized mortality ratio (SMR) for each patient group (TB, influenza and Salmonella) was calculated and compared. Kaplan-Meier survival curves were constructed for each group. <b>Results:</b> The all-cause SMR of TB patients was significantly increased (1.27 with 95%CI 1.2–1.34) compared to patients with salmonella, but not influenza (1.03 with 95%CI 0.97–1.1), infection. Risk factors for long-term mortality in TB patients included being male, over 59-years-old, sputum smear-positive, and having had intracranial disease. Respiratory and infectious causes of death were increased amongst TB cases, while patients with influenza experienced more cardiovascular deaths, compared to Salmonella patients. <b>Conclusion:</b> Compared to patients with documented Salmonella infection long-term mortality was significantly increased among both TB and influenza patients. Further research into the reasons for increased mortality after respiratory infections is warranted." @default.
- W4312581711 created "2023-01-05" @default.
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- W4312581711 date "2022-09-04" @default.
- W4312581711 modified "2023-10-12" @default.
- W4312581711 title "Increased long-term mortality among tuberculosis and influenza cases compared to patients with Salmonella infection" @default.
- W4312581711 doi "https://doi.org/10.1183/13993003.congress-2022.3592" @default.
- W4312581711 hasPublicationYear "2022" @default.
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