Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312585280> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4312585280 abstract "Cardiovascular diseases lead to long-term stiffening of arteries and small vessels. The vascular wall contains several cellular populations that coordinate to maintain vessel homeostasis and induce vascular remodeling in disease states. We identified a population of smooth muscle-derived progenitor cells that reside in the adventitial layer (AdvSca1-SM cells) that drive vascular fibrosis after acute vascular injury. AdvSca1-SM cells can differentiate into myofibroblasts and secrete numerous pro-remodeling factors including extracellular matrix proteins and pro-inflammatory cytokines. While the response of AdvSca1-SM cells to vascular injury has been studied, the epigenetic changes that influence their differentiation towards myofibroblasts is poorly understood. We observed Brahma-related gene 1 (Brg1), a highly conserved chromatin remodeling ATPase, is upregulated in AdvSca1-SM cells in response to vascular injury and may be a key factor in regulating gene expression to influence AdvSca1-SM differentiation. We hypothesize that Brg1 induces expression of gene sets associated with remodeling and fibrosis and ultimately drives AdvSca1-SM cell differentiation towards pathologic myofibroblasts. Results: Carotid arteries from mice subject to carotid ligation exhibit decreased perivascular collagen deposition, smaller neointima, decreased adventitial expansion, decreased numbers of alpha-actin positive AdvSca1-SM cells, and fewer infiltrating macrophages when treated with the pharmacological Brg1 bromodomain inhibitor PFI-3 as compared to mice that received vehicle control. In a cell culture system, TGF-β induces AdvSca1-SM cells to express myofibroblast-specific genes, including alpha actin and periostin, and demonstrate enhanced contractile function in collagen contraction assays. PFI-3 blocks TGF-β induced myofibroblast gene expression and dampens contractile function. Gene Ontology analysis reveals the top 100 TGF-β inducible genes blunted by PFI-3 are related to fibrosis and extracellular matrix signaling. In conclusion, these results suggest Brg1 is a major regulator of vascular remodeling and fibrosis and may be a targetable protein to help people who suffer from disease-related vascular stiffening." @default.
- W4312585280 created "2023-01-05" @default.
- W4312585280 creator A5014646586 @default.
- W4312585280 creator A5015988659 @default.
- W4312585280 creator A5047707609 @default.
- W4312585280 creator A5067011503 @default.
- W4312585280 creator A5075141440 @default.
- W4312585280 creator A5086428334 @default.
- W4312585280 creator A5087452663 @default.
- W4312585280 date "2022-05-01" @default.
- W4312585280 modified "2023-10-18" @default.
- W4312585280 title "Abstract 208: The Chromatin Remodeling Protein Brg1 Regulates Adventitial Progenitor Cell Myofibroblast Differentiation And Pathological Vascular Remodeling" @default.
- W4312585280 doi "https://doi.org/10.1161/atvb.42.suppl_1.208" @default.
- W4312585280 hasPublicationYear "2022" @default.
- W4312585280 type Work @default.
- W4312585280 citedByCount "0" @default.
- W4312585280 crossrefType "journal-article" @default.
- W4312585280 hasAuthorship W4312585280A5014646586 @default.
- W4312585280 hasAuthorship W4312585280A5015988659 @default.
- W4312585280 hasAuthorship W4312585280A5047707609 @default.
- W4312585280 hasAuthorship W4312585280A5067011503 @default.
- W4312585280 hasAuthorship W4312585280A5075141440 @default.
- W4312585280 hasAuthorship W4312585280A5086428334 @default.
- W4312585280 hasAuthorship W4312585280A5087452663 @default.
- W4312585280 hasConcept C104317684 @default.
- W4312585280 hasConcept C126322002 @default.
- W4312585280 hasConcept C134018914 @default.
- W4312585280 hasConcept C142724271 @default.
- W4312585280 hasConcept C148738053 @default.
- W4312585280 hasConcept C167227067 @default.
- W4312585280 hasConcept C189165786 @default.
- W4312585280 hasConcept C201750760 @default.
- W4312585280 hasConcept C207865475 @default.
- W4312585280 hasConcept C2777339539 @default.
- W4312585280 hasConcept C2778283817 @default.
- W4312585280 hasConcept C2778583881 @default.
- W4312585280 hasConcept C2779395532 @default.
- W4312585280 hasConcept C2780559512 @default.
- W4312585280 hasConcept C28328180 @default.
- W4312585280 hasConcept C2992686903 @default.
- W4312585280 hasConcept C41091548 @default.
- W4312585280 hasConcept C502942594 @default.
- W4312585280 hasConcept C55493867 @default.
- W4312585280 hasConcept C71924100 @default.
- W4312585280 hasConcept C86803240 @default.
- W4312585280 hasConcept C95444343 @default.
- W4312585280 hasConceptScore W4312585280C104317684 @default.
- W4312585280 hasConceptScore W4312585280C126322002 @default.
- W4312585280 hasConceptScore W4312585280C134018914 @default.
- W4312585280 hasConceptScore W4312585280C142724271 @default.
- W4312585280 hasConceptScore W4312585280C148738053 @default.
- W4312585280 hasConceptScore W4312585280C167227067 @default.
- W4312585280 hasConceptScore W4312585280C189165786 @default.
- W4312585280 hasConceptScore W4312585280C201750760 @default.
- W4312585280 hasConceptScore W4312585280C207865475 @default.
- W4312585280 hasConceptScore W4312585280C2777339539 @default.
- W4312585280 hasConceptScore W4312585280C2778283817 @default.
- W4312585280 hasConceptScore W4312585280C2778583881 @default.
- W4312585280 hasConceptScore W4312585280C2779395532 @default.
- W4312585280 hasConceptScore W4312585280C2780559512 @default.
- W4312585280 hasConceptScore W4312585280C28328180 @default.
- W4312585280 hasConceptScore W4312585280C2992686903 @default.
- W4312585280 hasConceptScore W4312585280C41091548 @default.
- W4312585280 hasConceptScore W4312585280C502942594 @default.
- W4312585280 hasConceptScore W4312585280C55493867 @default.
- W4312585280 hasConceptScore W4312585280C71924100 @default.
- W4312585280 hasConceptScore W4312585280C86803240 @default.
- W4312585280 hasConceptScore W4312585280C95444343 @default.
- W4312585280 hasIssue "Suppl_1" @default.
- W4312585280 hasLocation W43125852801 @default.
- W4312585280 hasOpenAccess W4312585280 @default.
- W4312585280 hasPrimaryLocation W43125852801 @default.
- W4312585280 hasRelatedWork W2057474081 @default.
- W4312585280 hasRelatedWork W2073032567 @default.
- W4312585280 hasRelatedWork W2133848287 @default.
- W4312585280 hasRelatedWork W2315987486 @default.
- W4312585280 hasRelatedWork W2580225965 @default.
- W4312585280 hasRelatedWork W2600526692 @default.
- W4312585280 hasRelatedWork W2773960426 @default.
- W4312585280 hasRelatedWork W3175842363 @default.
- W4312585280 hasRelatedWork W4210912804 @default.
- W4312585280 hasRelatedWork W4385614045 @default.
- W4312585280 hasVolume "42" @default.
- W4312585280 isParatext "false" @default.
- W4312585280 isRetracted "false" @default.
- W4312585280 workType "article" @default.