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- W4312596350 abstract "Animal research provides a major contribution to the discovery of new compounds and its mechanism of action. It also deals with the pharmacokinetics profile and determination of safe dose of a compound which is to be tested in humans. There is a necessity to choose an appropriate animal model for preclinical research in order to carry out a clinical trial. Research can be performed on already existing validated animal model or by validating a newer model. Validation criteria of an animal model changes from one to another based on the purpose of the model (fit-for-purpose). Face validity, predictive validity and construct validity ensures the closeness of the animal model to humans. In addition to these validity, few more criteria have been added to assess and optimise the animal model, i.e. epidemiology, symptomatology, natural history, end points, genetics, and biochemical parameters, pharmacological and histological features. There is no single animal model which can satisfy all types of validity for any disease. Even though shortcomings are inevitable, these models pave way for the safer research study in humans. One can choose an animal model closer to an ideal one. Thus validation plays a crucial role in translation of animal research to humans." @default.
- W4312596350 created "2023-01-05" @default.
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- W4312596350 date "2022-01-01" @default.
- W4312596350 modified "2023-09-26" @default.
- W4312596350 title "Validation of Animal Models" @default.
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- W4312596350 doi "https://doi.org/10.1007/978-981-19-5343-9_12" @default.
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