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- W4312607209 abstract "A total of 23 cyanobacteria cultures were extracted and sequentially solvent partitioned with hexane, n-butanol (n-BuOH), and water. The n-BuOH extracts were tested for antiproliferative effects against HCT116 human colorectal adenocarcinoma cells, anti-inflammatory activity on lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells, and antimalarial activity vs. Plasmodium falciparum W2. Eleven (11) and two extracts showed antiproliferative and anti-inflammatory activity, respectively. None of the extracts were antimalarial. Bioactivityguided purification of the n-BuOH extracts from Hapalosiphon welwitschii Cy 51 and Oscillatoria obscura Cy 13 yielded seven antiproliferative indole alkaloids. This work highlights the potential of terrestrial and freshwater cyanobacteria from the Philippines as a source of bioactive and structurally diverse natural products." @default.
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- W4312607209 date "2021-08-09" @default.
- W4312607209 modified "2023-10-16" @default.
- W4312607209 title "Biological Activity and Chemical Profiling of Terrestrial and Freshwater Cyanobacteria from the Philippines" @default.
- W4312607209 doi "https://doi.org/10.56899/150.05.34" @default.
- W4312607209 hasPublicationYear "2021" @default.
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