Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312608857> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4312608857 endingPage "113" @default.
- W4312608857 startingPage "81" @default.
- W4312608857 abstract "The discovery of new PROTAC molecules is dependent on robust and high-throughput assays to measure PROTAC-protein interactions and ternary complex formation. Here we present the optimization and execution of Lumit Immunoassays to measure PROTAC binding and ternary complex formation in a biochemical format. We demonstrate how Lumit can be used to rank order affinities of small molecules and PROTACs to BRD4(BD1, BD2) and how to measure PROTAC-mediated ternary complex formation of BRD4(BD1, BD2) and E3 Ligase VHL. Results from both biochemical assays correlate with live and lytic cell assays, indicating that Lumit Immunoassays can be used as a high-throughput compatible screening methodology to test new small molecules." @default.
- W4312608857 created "2023-01-05" @default.
- W4312608857 creator A5003828846 @default.
- W4312608857 creator A5024668347 @default.
- W4312608857 creator A5040662926 @default.
- W4312608857 creator A5046763626 @default.
- W4312608857 creator A5050845134 @default.
- W4312608857 creator A5060989181 @default.
- W4312608857 creator A5091797723 @default.
- W4312608857 date "2023-01-01" @default.
- W4312608857 modified "2023-09-26" @default.
- W4312608857 title "Monitoring PROTAC interactions in biochemical assays using Lumit immunoassays" @default.
- W4312608857 cites W1512690422 @default.
- W4312608857 cites W2151683271 @default.
- W4312608857 cites W2226712470 @default.
- W4312608857 cites W2595729735 @default.
- W4312608857 cites W2888598609 @default.
- W4312608857 cites W2904154756 @default.
- W4312608857 cites W2936661052 @default.
- W4312608857 cites W2948220248 @default.
- W4312608857 cites W2994376311 @default.
- W4312608857 cites W2998236399 @default.
- W4312608857 cites W3133538605 @default.
- W4312608857 cites W3185051064 @default.
- W4312608857 cites W3194448573 @default.
- W4312608857 cites W3201236410 @default.
- W4312608857 cites W4220906618 @default.
- W4312608857 cites W4282935641 @default.
- W4312608857 doi "https://doi.org/10.1016/bs.mie.2022.08.055" @default.
- W4312608857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36764765" @default.
- W4312608857 hasPublicationYear "2023" @default.
- W4312608857 type Work @default.
- W4312608857 citedByCount "0" @default.
- W4312608857 crossrefType "book-chapter" @default.
- W4312608857 hasAuthorship W4312608857A5003828846 @default.
- W4312608857 hasAuthorship W4312608857A5024668347 @default.
- W4312608857 hasAuthorship W4312608857A5040662926 @default.
- W4312608857 hasAuthorship W4312608857A5046763626 @default.
- W4312608857 hasAuthorship W4312608857A5050845134 @default.
- W4312608857 hasAuthorship W4312608857A5060989181 @default.
- W4312608857 hasAuthorship W4312608857A5091797723 @default.
- W4312608857 hasConcept C161624437 @default.
- W4312608857 hasConcept C181199279 @default.
- W4312608857 hasConcept C185592680 @default.
- W4312608857 hasConcept C199360897 @default.
- W4312608857 hasConcept C41008148 @default.
- W4312608857 hasConcept C51323132 @default.
- W4312608857 hasConcept C55493867 @default.
- W4312608857 hasConcept C64452783 @default.
- W4312608857 hasConcept C70721500 @default.
- W4312608857 hasConcept C86756495 @default.
- W4312608857 hasConcept C86803240 @default.
- W4312608857 hasConceptScore W4312608857C161624437 @default.
- W4312608857 hasConceptScore W4312608857C181199279 @default.
- W4312608857 hasConceptScore W4312608857C185592680 @default.
- W4312608857 hasConceptScore W4312608857C199360897 @default.
- W4312608857 hasConceptScore W4312608857C41008148 @default.
- W4312608857 hasConceptScore W4312608857C51323132 @default.
- W4312608857 hasConceptScore W4312608857C55493867 @default.
- W4312608857 hasConceptScore W4312608857C64452783 @default.
- W4312608857 hasConceptScore W4312608857C70721500 @default.
- W4312608857 hasConceptScore W4312608857C86756495 @default.
- W4312608857 hasConceptScore W4312608857C86803240 @default.
- W4312608857 hasLocation W43126088571 @default.
- W4312608857 hasLocation W43126088572 @default.
- W4312608857 hasOpenAccess W4312608857 @default.
- W4312608857 hasPrimaryLocation W43126088571 @default.
- W4312608857 hasRelatedWork W1995979404 @default.
- W4312608857 hasRelatedWork W2000304827 @default.
- W4312608857 hasRelatedWork W2006511412 @default.
- W4312608857 hasRelatedWork W2023265819 @default.
- W4312608857 hasRelatedWork W2092152178 @default.
- W4312608857 hasRelatedWork W2125782931 @default.
- W4312608857 hasRelatedWork W2565654508 @default.
- W4312608857 hasRelatedWork W2585514319 @default.
- W4312608857 hasRelatedWork W4362457744 @default.
- W4312608857 hasRelatedWork W4379390441 @default.
- W4312608857 isParatext "false" @default.
- W4312608857 isRetracted "false" @default.
- W4312608857 workType "book-chapter" @default.