FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312615442> ?p ?o ?g. }

• W4312615442 endingPage "612" @default.
• W4312615442 startingPage "605" @default.
• W4312615442 abstract "Abstract Human CD38, a surface molecule expressed by immature and activated T and B lymphocytes, has been characterized as a molecule transducing activation and proliferation signals, and intervening in adhesion to endothelium via its ligand CD31. CD38 is also a complex ectoenzyme featuring ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities, leading to the synthesis and degradation of cADPR, a Ca+-mobilizing agent. We investigated the effects of monocyte-activating stimuli (IFN-γ, IL-2, LPS, TNF-α, and GM-CSF) on the expression and function of CD38, starting from the observation that human monocytes and the derived lines U937, THP-1, and Mono-Mac-6 bear the molecule on their surface. Our results indicate that IFN-γ is a strong up-modulator of CD38, and IL-2 increases its expression only modestly. LPS, TNF-α, and GM-CSF had no detectable effects. Treatment with IFN-γ produced a dose- and time-dependent up-regulation of CD38 in monocytes and monocytic lines, which was paralleled by increased ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities. Furthermore, CD38 ligation by specific MoAb reduced the IFN-γ-dependent enhancement of monocyte-dynamic adhesion to endothelial monolayers. These findings identify IFN-γ as a modulator of monocytic CD38 expression and indicate that CD38 plays a specific role in the activation and adhesion processes performed by monocytes." @default.
• W4312615442 created "2023-01-05" @default.
• W4312615442 creator A5007447330 @default.
• W4312615442 creator A5017082398 @default.
• W4312615442 creator A5030390675 @default.
• W4312615442 creator A5032770201 @default.
• W4312615442 creator A5033741627 @default.
• W4312615442 creator A5045628606 @default.
• W4312615442 creator A5064847334 @default.
• W4312615442 creator A5068535005 @default.
• W4312615442 date "2001-04-01" @default.
• W4312615442 modified "2023-10-10" @default.
• W4312615442 title "CD38 expression and functional activities are up-regulated by IFN-γ on human monocytes and monocytic cell lines" @default.
• W4312615442 cites W1483624903 @default.
• W4312615442 cites W1488869774 @default.
• W4312615442 cites W1536803321 @default.
• W4312615442 cites W1575893280 @default.
• W4312615442 cites W1968370221 @default.
• W4312615442 cites W1970572171 @default.
• W4312615442 cites W1980487593 @default.
• W4312615442 cites W1981070227 @default.
• W4312615442 cites W1989090634 @default.
• W4312615442 cites W1999644793 @default.
• W4312615442 cites W2003353539 @default.
• W4312615442 cites W2005190805 @default.
• W4312615442 cites W2053432866 @default.
• W4312615442 cites W2061984547 @default.
• W4312615442 cites W2063964202 @default.
• W4312615442 cites W2074701257 @default.
• W4312615442 cites W2078953009 @default.
• W4312615442 cites W2082340361 @default.
• W4312615442 cites W2089099331 @default.
• W4312615442 cites W2104121919 @default.
• W4312615442 cites W2140612321 @default.
• W4312615442 cites W2142589520 @default.
• W4312615442 cites W2159519807 @default.
• W4312615442 cites W2172715533 @default.
• W4312615442 cites W2191654227 @default.
• W4312615442 cites W3112369798 @default.
• W4312615442 doi "https://doi.org/10.1189/jlb.69.4.605" @default.
• W4312615442 hasPublicationYear "2001" @default.
• W4312615442 type Work @default.
• W4312615442 citedByCount "52" @default.
• W4312615442 countsByYear W43126154422012 @default.
• W4312615442 countsByYear W43126154422013 @default.
• W4312615442 countsByYear W43126154422014 @default.
• W4312615442 countsByYear W43126154422015 @default.
• W4312615442 countsByYear W43126154422016 @default.
• W4312615442 countsByYear W43126154422017 @default.
• W4312615442 countsByYear W43126154422018 @default.
• W4312615442 countsByYear W43126154422020 @default.
• W4312615442 countsByYear W43126154422021 @default.
• W4312615442 countsByYear W43126154422022 @default.
• W4312615442 countsByYear W43126154422023 @default.
• W4312615442 crossrefType "journal-article" @default.
• W4312615442 hasAuthorship W4312615442A5007447330 @default.
• W4312615442 hasAuthorship W4312615442A5017082398 @default.
• W4312615442 hasAuthorship W4312615442A5030390675 @default.
• W4312615442 hasAuthorship W4312615442A5032770201 @default.
• W4312615442 hasAuthorship W4312615442A5033741627 @default.
• W4312615442 hasAuthorship W4312615442A5045628606 @default.
• W4312615442 hasAuthorship W4312615442A5064847334 @default.
• W4312615442 hasAuthorship W4312615442A5068535005 @default.
• W4312615442 hasConcept C10205521 @default.
• W4312615442 hasConcept C108634530 @default.
• W4312615442 hasConcept C1491633281 @default.
• W4312615442 hasConcept C153911025 @default.
• W4312615442 hasConcept C159912055 @default.
• W4312615442 hasConcept C16224149 @default.
• W4312615442 hasConcept C17991360 @default.
• W4312615442 hasConcept C202751555 @default.
• W4312615442 hasConcept C203014093 @default.
• W4312615442 hasConcept C204258353 @default.
• W4312615442 hasConcept C2781184567 @default.
• W4312615442 hasConcept C28328180 @default.
• W4312615442 hasConcept C2909375385 @default.
• W4312615442 hasConcept C54355233 @default.
• W4312615442 hasConcept C55493867 @default.
• W4312615442 hasConcept C81885089 @default.
• W4312615442 hasConcept C85789140 @default.
• W4312615442 hasConcept C86803240 @default.
• W4312615442 hasConcept C95444343 @default.
• W4312615442 hasConceptScore W4312615442C10205521 @default.
• W4312615442 hasConceptScore W4312615442C108634530 @default.
• W4312615442 hasConceptScore W4312615442C1491633281 @default.
• W4312615442 hasConceptScore W4312615442C153911025 @default.
• W4312615442 hasConceptScore W4312615442C159912055 @default.
• W4312615442 hasConceptScore W4312615442C16224149 @default.
• W4312615442 hasConceptScore W4312615442C17991360 @default.
• W4312615442 hasConceptScore W4312615442C202751555 @default.
• W4312615442 hasConceptScore W4312615442C203014093 @default.
• W4312615442 hasConceptScore W4312615442C204258353 @default.
• W4312615442 hasConceptScore W4312615442C2781184567 @default.
• W4312615442 hasConceptScore W4312615442C28328180 @default.
• W4312615442 hasConceptScore W4312615442C2909375385 @default.
• W4312615442 hasConceptScore W4312615442C54355233 @default.
• W4312615442 hasConceptScore W4312615442C55493867 @default.
• W4312615442 hasConceptScore W4312615442C81885089 @default.

• next