Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312622054> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4312622054 endingPage "29" @default.
- W4312622054 startingPage "23" @default.
- W4312622054 abstract "HIV-1 or Human Immuno Deficiency Virus-1 is the main causative agent of Acquired Immuno Deficiency Syndrome (AIDS). Human host infected with HIV - 1 extensively harbours many viral variants but very little is known about the difference in pattern [17] of evolution of phylogenetic lineages of HIV-1 non recombinant, normal inter subtype recombinant and main two specific recombinant forms of HIV-1 i.e., Circulating Recombinant Forms (CRFs) and Unique Recombinant Forms (URFs). This study is mainly concerned with study of the difference in evolutionary lineages of non-recombinant and recombinant sequences of HIV-1 genome sequences and identification of geographically rich areas which has reported high degree of HIV-1 occurrence and variety. Total 1550 HIV-1 genome sequences were obtained from HIV Los Alamos Database. The sequences were aligned using MAFFT (Multiple Alignment using Fast Fourier Transform) web server tool. Alignment was carried out using 10 different set of alignment parameter values. After alignment the aligned file was used for constructing N-J phylogenetic tree using Clustal X2 tool. Phylogenetic analysis was performed keeping in mind the category to which the sequence belongs. Upon analysis it was observed that the clade containing the probable ancestor belongs remained constant in all cases of different alignment values. Non recombinant isolates, inter subtype recombinants, CRFs, URFs all followed different patterns of evolution. Non recombinant sequences were found geographically specific and subtype specific to some extent whereas, normal recombinants were subtype specific and less geographically specific. CRFs showed variation among the pattern of their evolution. At some instances the sequences occurred as sister taxa of non-recombinant or normal inter subtype recombinant sequences, while at some instances as sister taxa of other CRFs where they were geographically specific. Three CRFs existed as completely diverged sequences. URFs were four in number; two of them were Indian isolates of while other two were Japanese isolates. URFs were found to be totally geographically specific. Geography wise high rate of variation was observed in India and Japan as these two countries had sequences belonging to all of the above categories. Cameroon and South Africa have very large number isolates and a considerable amount of genetic variation among isolates but they lack URFs." @default.
- W4312622054 created "2023-01-05" @default.
- W4312622054 creator A5008633245 @default.
- W4312622054 creator A5017266613 @default.
- W4312622054 creator A5025390051 @default.
- W4312622054 creator A5034795112 @default.
- W4312622054 creator A5049487173 @default.
- W4312622054 creator A5068275851 @default.
- W4312622054 date "2013-12-17" @default.
- W4312622054 modified "2023-09-27" @default.
- W4312622054 title "Identifying Overlapping Phylogenetic and Geographic Roots of HIV – 1 Evolution through Computational Analyses" @default.
- W4312622054 doi "https://doi.org/10.56431/p-3om0n3" @default.
- W4312622054 hasPublicationYear "2013" @default.
- W4312622054 type Work @default.
- W4312622054 citedByCount "0" @default.
- W4312622054 crossrefType "journal-article" @default.
- W4312622054 hasAuthorship W4312622054A5008633245 @default.
- W4312622054 hasAuthorship W4312622054A5017266613 @default.
- W4312622054 hasAuthorship W4312622054A5025390051 @default.
- W4312622054 hasAuthorship W4312622054A5034795112 @default.
- W4312622054 hasAuthorship W4312622054A5049487173 @default.
- W4312622054 hasAuthorship W4312622054A5068275851 @default.
- W4312622054 hasBestOaLocation W43126220542 @default.
- W4312622054 hasConcept C104317684 @default.
- W4312622054 hasConcept C141231307 @default.
- W4312622054 hasConcept C152565575 @default.
- W4312622054 hasConcept C159047783 @default.
- W4312622054 hasConcept C167625842 @default.
- W4312622054 hasConcept C17966761 @default.
- W4312622054 hasConcept C193252679 @default.
- W4312622054 hasConcept C204321447 @default.
- W4312622054 hasConcept C2775953691 @default.
- W4312622054 hasConcept C40767141 @default.
- W4312622054 hasConcept C41008148 @default.
- W4312622054 hasConcept C44465124 @default.
- W4312622054 hasConcept C45484198 @default.
- W4312622054 hasConcept C54355233 @default.
- W4312622054 hasConcept C70721500 @default.
- W4312622054 hasConcept C78458016 @default.
- W4312622054 hasConcept C86803240 @default.
- W4312622054 hasConcept C8769409 @default.
- W4312622054 hasConcept C88031987 @default.
- W4312622054 hasConcept C90132467 @default.
- W4312622054 hasConcept C90856448 @default.
- W4312622054 hasConceptScore W4312622054C104317684 @default.
- W4312622054 hasConceptScore W4312622054C141231307 @default.
- W4312622054 hasConceptScore W4312622054C152565575 @default.
- W4312622054 hasConceptScore W4312622054C159047783 @default.
- W4312622054 hasConceptScore W4312622054C167625842 @default.
- W4312622054 hasConceptScore W4312622054C17966761 @default.
- W4312622054 hasConceptScore W4312622054C193252679 @default.
- W4312622054 hasConceptScore W4312622054C204321447 @default.
- W4312622054 hasConceptScore W4312622054C2775953691 @default.
- W4312622054 hasConceptScore W4312622054C40767141 @default.
- W4312622054 hasConceptScore W4312622054C41008148 @default.
- W4312622054 hasConceptScore W4312622054C44465124 @default.
- W4312622054 hasConceptScore W4312622054C45484198 @default.
- W4312622054 hasConceptScore W4312622054C54355233 @default.
- W4312622054 hasConceptScore W4312622054C70721500 @default.
- W4312622054 hasConceptScore W4312622054C78458016 @default.
- W4312622054 hasConceptScore W4312622054C86803240 @default.
- W4312622054 hasConceptScore W4312622054C8769409 @default.
- W4312622054 hasConceptScore W4312622054C88031987 @default.
- W4312622054 hasConceptScore W4312622054C90132467 @default.
- W4312622054 hasConceptScore W4312622054C90856448 @default.
- W4312622054 hasLocation W43126220541 @default.
- W4312622054 hasLocation W43126220542 @default.
- W4312622054 hasOpenAccess W4312622054 @default.
- W4312622054 hasPrimaryLocation W43126220541 @default.
- W4312622054 hasRelatedWork W2054754315 @default.
- W4312622054 hasRelatedWork W2097481614 @default.
- W4312622054 hasRelatedWork W2122359836 @default.
- W4312622054 hasRelatedWork W2133420109 @default.
- W4312622054 hasRelatedWork W2507299665 @default.
- W4312622054 hasRelatedWork W2967147551 @default.
- W4312622054 hasRelatedWork W3025626435 @default.
- W4312622054 hasRelatedWork W4213087523 @default.
- W4312622054 hasRelatedWork W4229858997 @default.
- W4312622054 hasRelatedWork W4303468867 @default.
- W4312622054 hasVolume "7" @default.
- W4312622054 isParatext "false" @default.
- W4312622054 isRetracted "false" @default.
- W4312622054 workType "article" @default.