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• W4312650196 abstract "Leukocyte adhesion deficiency type-1 (LAD-1) is a rare primary immunodeficiency that is characterised by compromised neutrophil adhesion and transmigration to infection or inflammation sites. In this article, the authors report the cases of five patients with LAD-1 deficiency. The aim of this study is the demonstration of the wide variety of manifestations in these patients with a review of the literature. Patients were both male and female, with their ages ranging from 1 month to 10 years old. Omphalitis was the most common presentation in this series, followed by pneumonia and gingivitis. Impaired wound healing and cellulitis were other common findings in these patients. Two of the patients did not show delayed separation of the umbilical cord. The findings indicate that LAD-1 remains a life-threatening condition with omphalitis, oral, skin, respiratory tract, and ear infections as the most common complications. Early identification of these patients is essential in ensuring a definitive diagnosis and early implementation of haematopoietic stem cell transplantation." @default.
• W4312650196 created "2023-01-05" @default.
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• W4312650196 date "2019-07-18" @default.
• W4312650196 modified "2023-10-16" @default.
• W4312650196 title "Leukocyte Adhesion Deficiency Type 1: A Case Series and Review of the Literature" @default.
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• W4312650196 doi "https://doi.org/10.33590/emjallergyimmunol/10314214" @default.
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