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- W4312658573 abstract "<b>Introduction:</b> Despite substantial clinical benefits of biologics in severe asthma, real-world data presented heterogenous treatment response among patients. <b>Aim:</b> To identify the baseline characteristics of responders to biologics depending on assessed domains of asthma including acute exacerbation(AE), lung function, ACT score, and OCS use. <b>Methods:</b> We have conducted a prospective study in patients with severe asthma, named ‘Precision Medicine Intervention in Severe Asthma(PRISM)’. The data of the participants treated with biologics for at least 6 months were analysed. <b>Results:</b> A total of 91 patients received biologics targeting eosinophilic inflammation (27 mepolizumab, 37 reslizumab, and 27 dupilumab). The patients with no AE during treatment reported lower number of previous AE (2.71±4.55 vs. 7.82±6.08, p<0.001) and white blood cell count (X 10<sup>3</sup>/uL) (7.88±2.44 vs. 9.24±1.97, p=0.023) compared to the participants who had at least one exacerbation. The participants showing improved lung function (FEV1≥ 100mL and 10%) had higher blood eosinophil counts (787.98±693.83 vs. 551.63±361.42d, p=0.040) and lower FEV1(%) (56.92±17.55 vs. 67.05±20.76, p=0.015) compared to the others. Regarding ACT score, only higher level of blood eosinophils at baseline was noted in the participants whose score increased by 3 or greater than the others (780.06±612.13 vs. 496.93±489.70, p=0.027). Among the maintenance OCS users, characteristics were similar irrespective of complete OCS withdrawal after 6-month treatment. <b>Conclusions:</b> The clinical characteristics of the responders varied according to assessed domains of asthma, warranting further mechanistical study." @default.
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- W4312658573 date "2022-09-04" @default.
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- W4312658573 title "Characteristics of Responders to Biologics in Patients with Severe Asthma: Based on Precision Medicine Intervention in Severe Asthma (PRISM) Study" @default.
- W4312658573 doi "https://doi.org/10.1183/13993003.congress-2022.3383" @default.
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