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- W4312681428 abstract "<b>Background:</b> Common variable immunodeficiency (CVID) is a heterogeneous group of disorders characterized by hypogammaglobulinemia, impaired production of antigen-specific antibodies, and immune system dysregulation that predispose particularly to recurrent and/or chronic bacterial respiratory tract infections and a broad spectrum of non-infectious complications including autoimmune, lymphoproliferative and/or granulomatous diseases. In previous studies, interstitial lung disease (ILD) has been described in 10-25% of CVID patients. It significantly affects their quality of life and reduces survival. <b>Methods:</b> Cross-sectional nationwide multicenter study including 100 CVID patients from 6 national centers for diagnostics and treatment of inborn errors of immunity. CT/HRCT, bodypletysmography, diffusing lung capacity (DLCO), immunological parameters, T and B cell immunophenotyping, quality of life assessment (SF-36 and K-BILD questionnaires) were performed in all enrolled patients. <b>Results:</b> Bronchiectasis and multiple lung granuloma were the most common CT findings. The presence of ILD correlated with impaired DLCO (and bodypletysmography in more severe cases) and other non-infectious manifestations. It also significantly affected the quality of life. <b>Conclusions:</b> Chronic lung disease belongs to one of the most common manifestations of CVID that significantly impaired lung functions and interfere with the quality of life." @default.
- W4312681428 created "2023-01-05" @default.
- W4312681428 creator A5069663556 @default.
- W4312681428 date "2022-09-04" @default.
- W4312681428 modified "2023-09-28" @default.
- W4312681428 title "Lung manifestation of Common variable immunodeficiency – the results from the nationwide multicenter study" @default.
- W4312681428 doi "https://doi.org/10.1183/13993003.congress-2022.3513" @default.
- W4312681428 hasPublicationYear "2022" @default.
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