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- W4312681907 abstract "<b>Background:</b> Transbronchial lung cryobiopsy (TBLC) has been recently introduced in the diagnostic process of diffuse parenchymal lung diseases. There are many potential advantages of TBLC over surgical biopsy, including faster recovery time and lower risk of adverse events. However, there are no prospective specific studies evaluating whether TBLC may be associated with a permanent reduction of lung function. <b>Methods:</b> This is an observational, prospective, monocentric study of consecutive patients with diffuse parenchymal lung diseases undergoing transbronchial lung cryobiopsy. Primary endpoint was the variation in forced vital capacity (FVC) before and after cryobiopsy. Secondary endpoints were the variations in forced expiratory volume in one second (FEV1), carbon monoxide diffusion capacity (DLCO), and morbidity and mortality associated with the procedure. <b>Results:</b> In 60 patients who underwent TBLC for diffuse parenchymal lung diseases, a significant change in FVC was not observed (p 0.931) between measurements performed before and after the procedure. Significant changes were not observed also after TBLC in FEV1, TLC, and DLCO. Complications within 30 days of cryobiopsy (pneumothorax and/or mild/moderate bleeding) occurred in 7.1% of patients. No deaths were observed within 30 days. <b>Conclusion:</b> In this prospective study in patients with diffuse parenchymal lung diseases, trans-bronchial lung cryobiopsy was not associated with increased risk of acute exacerbation or decline in lung function." @default.
- W4312681907 created "2023-01-05" @default.
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- W4312681907 date "2022-09-04" @default.
- W4312681907 modified "2023-09-27" @default.
- W4312681907 title "Impact of transbronchial lung cryobiopsy on lung function in patients with interstitial lung diseases" @default.
- W4312681907 doi "https://doi.org/10.1183/13993003.congress-2022.2795" @default.
- W4312681907 hasPublicationYear "2022" @default.
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