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- W4312690216 abstract "A new 1, 2, 3-trisubstituted-γ-lactams were designed and synthesized through the reaction of mono and bis imines with 3-(4-substituted phenyl) dihydrofuran-2, 5-dione to obtain a 1, 2, 3-trisubstituted-γ-lactams 4(a-h). Furthermore, this study examined the antioxidant activity of these synthesize compounds. Some of the synthesized compounds show high antioxidant effects, these effects examined by using 1,1diphenyl-2picrylhydrazyl (DPPH) free radical scavenging examination. Cellular toxicity has been studied compounds 4 (a-h) on the cell lines (MCF-7) using the MTT assay that revealed the presence of a toxic effect of the cells with the highest activity of the compound 4a on (MCF-7) cell lines. The compounds were recognized on the basis of the spectral examinations utilizing 1H-NMR, 13C-NMR, IR." @default.
- W4312690216 created "2023-01-05" @default.
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- W4312690216 date "2022-01-01" @default.
- W4312690216 modified "2023-10-17" @default.
- W4312690216 title "Synthesis, spectral characterization, antioxidant and anticancer evaluation of 1, 2, 3-trisubstituted-γ-lactams" @default.
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- W4312690216 doi "https://doi.org/10.1063/5.0093789" @default.
- W4312690216 hasPublicationYear "2022" @default.
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