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• W4312691566 abstract "<b>Objective:</b> To determine the frequency and outcomes of invasive pulmonary aspergillosis (IPA) in patients with influenza, COVID-19 and community acquired pneumonia (CAP) admitted in critical care units of a tertiary care hospital in Pakistan. <b>Methods:</b> A prospective cross sectional study was conducted at the Aga Khan University from Nov 2019-June 2020. Adult patients admitted in critical care units with CAP, influenza and COVID-19 pneumonia were included. IPA was diagnosed as per EORTC/MSG criteria. Clinical information and outcome were collected on predesigned performa. <b>Results:</b> A total of 140 patients [70 Influenza, 35 COVID-19 and 35 CAP] were included. Of total, 20(14.2%) patients were found to have invasive aspergillosis with 10/35(28.5%), 9/75(12.8%) and 1/35(2.8%) patients in COVID-19, influenza and CAP groups, respectively. Duration of symptoms was 12.5±12.13 days in CAPA and 7.56±4.0 days in IAPA patients (p=0.24). Mean APCHE II score was 17.4±8.42 and 16.6±6.27 in patients with CAPA and IAPA respectively (p=0.85). 9(90%) CAPA patients required vasopressor support compared to 3(33%) patients in IAPA (p=0.020). 7(70%) CAPA patients required invasive mechanical ventilation compared to 4(44%) IAPA patients (p=0.37). Length of stay in hospital was highest in CAPA patients (18.3±7.28 days) compared to IAPA patients (11.7±5.33 days) (p=0.036). The number of deaths in IAPA patients and CAPA patients was 3(33.3%) and 5(50%), respectively (p=0.526). <b>Conclusion:</b> A higher proportion of patients with COVID-19 developed IPA compared to influenza and CAP. CAPA patients had a significantly longer stay in hospital and mortality." @default.
• W4312691566 created "2023-01-05" @default.
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• W4312691566 date "2022-09-04" @default.
• W4312691566 modified "2023-09-28" @default.
• W4312691566 title "Comparison of clinical features, risk factors and outcome of invasive pulmonary aspergillosis in critically ill COVID-19, influenza and community acquired pneumonia patients" @default.
• W4312691566 doi "https://doi.org/10.1183/13993003.congress-2022.2457" @default.
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