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- W4312722511 abstract "Introduction: Surgical resection is the main treatment for intrahepatic cholangiocarcinoma (ICC). The presence of multifocal lesions is one of the poor prognostic factors. This study aimed to investigate the overall survival of multifocal ICC in surgically resected patients. Methods: We retrospectively reviewed 407 consecutive patients with ICC who underwent laparotomy between October 2013 to December 2018. We excluded unresectable patients. Patients were divided into neither multifocal lesions nor pM1 (A), only multifocal lesions (B), only pM1 (C), and both multifocal lesion and pM1 (D). The overall survival and clinicopathological characteristics were compared among the groups. Results: Of the 407 patients, 101 patients were unresectable and 306 patients underwent surgical resection. There were 212, 62, 20, 12 patients in group A, B, C, and D respectively. The resection margin, histological grading, lymphovascular invasion, perineural invasion, AJCC 8th TMN staging were the difference characteristics among the groups. The median survival time (MST) were 14.7, 8.7, 6.5, and 3.1 months respectively (p<0.001). The adjusted overall survivals were not different between B and C (HR 1.04, p 0.972, B vs. C). The adjusted overall survival in D was the worst but not statistically significance (HR 1.86, p 0.589, D vs. B) (HR 1.95, p 0.254, D vs. C). Conclusion: The adjusted overall survival in the multifocal lesions group was not different to the pathological proven metastasis group. Surgical resection should be done only in some selected patients with multidisciplinary team approach." @default.
- W4312722511 created "2023-01-05" @default.
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- W4312722511 date "2022-01-01" @default.
- W4312722511 modified "2023-09-27" @default.
- W4312722511 title "Should Multifocal Intrahepatic Cholangiocarcinoma Be Considered as Metastasis in Surgically Resected Patients?" @default.
- W4312722511 doi "https://doi.org/10.1016/j.hpb.2022.05.324" @default.
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