Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312755787> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4312755787 endingPage "870" @default.
- W4312755787 startingPage "865" @default.
- W4312755787 abstract "Diclofenac potassium was synthesized from aniline and chloroacetyl chloride. The reaction of diclofenac potassium with calcium sulphate dihydrate and ammonium sulphate yielded diclofenac calcium and diclofenac ammonium, respectively. After diclofenac potassium was acidized with hydrochloride, the esterification of attained diclofenac with absolute methanol and absolute ethanol yielded compounds diclofenac methyl ester and diclofenac ethyl ester, respectively. Among the five compounds, diclofenac calcium and diclofenac ammonium are new compounds, and their synthetic methods have not been reported in the world. Every synthesized compound and intermediate were measured their 1 H-NMR, 13 C-NMR spectra. Analgesic activity of the target compounds was screened using acetic acid writhing test of mice and anti-inflammatory activity of the compounds was tested by xylene-induced ear swelling of mice. The results showed that all the 5 compounds had strong analgesic activity and anti-inflammatory activity. Among them, diclofenac methyl ester is the strongest, its analgesic and anti-inflammatory effects were stronger than the clinical use of diclofenac potassium." @default.
- W4312755787 created "2023-01-05" @default.
- W4312755787 creator A5010435688 @default.
- W4312755787 creator A5029563593 @default.
- W4312755787 creator A5045515858 @default.
- W4312755787 creator A5057631131 @default.
- W4312755787 creator A5077746159 @default.
- W4312755787 creator A5084854649 @default.
- W4312755787 date "2022-06-01" @default.
- W4312755787 modified "2023-09-23" @default.
- W4312755787 title "Synthesis, anti-inflammatory and analgesia activities of diclofenac and their derivatives" @default.
- W4312755787 doi "https://doi.org/10.1166/mex.2022.2209" @default.
- W4312755787 hasPublicationYear "2022" @default.
- W4312755787 type Work @default.
- W4312755787 citedByCount "0" @default.
- W4312755787 crossrefType "journal-article" @default.
- W4312755787 hasAuthorship W4312755787A5010435688 @default.
- W4312755787 hasAuthorship W4312755787A5029563593 @default.
- W4312755787 hasAuthorship W4312755787A5045515858 @default.
- W4312755787 hasAuthorship W4312755787A5057631131 @default.
- W4312755787 hasAuthorship W4312755787A5077746159 @default.
- W4312755787 hasAuthorship W4312755787A5084854649 @default.
- W4312755787 hasConcept C13965031 @default.
- W4312755787 hasConcept C178790620 @default.
- W4312755787 hasConcept C185592680 @default.
- W4312755787 hasConcept C2779244968 @default.
- W4312755787 hasConcept C2779826273 @default.
- W4312755787 hasConcept C2780820201 @default.
- W4312755787 hasConcept C2908765736 @default.
- W4312755787 hasConcept C43617362 @default.
- W4312755787 hasConcept C517785266 @default.
- W4312755787 hasConcept C55493867 @default.
- W4312755787 hasConcept C71924100 @default.
- W4312755787 hasConcept C98274493 @default.
- W4312755787 hasConceptScore W4312755787C13965031 @default.
- W4312755787 hasConceptScore W4312755787C178790620 @default.
- W4312755787 hasConceptScore W4312755787C185592680 @default.
- W4312755787 hasConceptScore W4312755787C2779244968 @default.
- W4312755787 hasConceptScore W4312755787C2779826273 @default.
- W4312755787 hasConceptScore W4312755787C2780820201 @default.
- W4312755787 hasConceptScore W4312755787C2908765736 @default.
- W4312755787 hasConceptScore W4312755787C43617362 @default.
- W4312755787 hasConceptScore W4312755787C517785266 @default.
- W4312755787 hasConceptScore W4312755787C55493867 @default.
- W4312755787 hasConceptScore W4312755787C71924100 @default.
- W4312755787 hasConceptScore W4312755787C98274493 @default.
- W4312755787 hasIssue "6" @default.
- W4312755787 hasLocation W43127557871 @default.
- W4312755787 hasOpenAccess W4312755787 @default.
- W4312755787 hasPrimaryLocation W43127557871 @default.
- W4312755787 hasRelatedWork W1968153943 @default.
- W4312755787 hasRelatedWork W2049131783 @default.
- W4312755787 hasRelatedWork W2102548330 @default.
- W4312755787 hasRelatedWork W2153096616 @default.
- W4312755787 hasRelatedWork W2155181578 @default.
- W4312755787 hasRelatedWork W2187496725 @default.
- W4312755787 hasRelatedWork W2353344284 @default.
- W4312755787 hasRelatedWork W2952364380 @default.
- W4312755787 hasRelatedWork W3195914969 @default.
- W4312755787 hasRelatedWork W2182844372 @default.
- W4312755787 hasVolume "12" @default.
- W4312755787 isParatext "false" @default.
- W4312755787 isRetracted "false" @default.
- W4312755787 workType "article" @default.