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• W4312756594 abstract "Cell fate decisions of hematopoietic progenitor cells (HSPCs) are controlled by extrinsic signals from their niches. Cytokines promote HSPC survival and/or proliferation. However, whether cytokines can also directly instruct HSPCs to differentiate into specific lineages (lineage instruction model), or only promote the survival and/or proliferation of cells, which have already intrinsically committed to a specific lineage (permissive model), remains disputed. In case of lineage instruction, cytokine signaling would activate the molecular programs initiating lineage choice, thus enabling important insights into its molecular regulation. Despite the fundamental importance of this question, it has not been analyzed for most cell types and cytokines. This is due to the demanding technology required for a quantitative proof: to rule out the exclusively permissive model, all clonal progeny of differentiating HSPCs must be observed throughout their lineage commitment process to exclude even single cell death events. Here, we therefore combined long-term imaging and cell tracking to quantify the cell fates of individual HSPCs and all their progeny over many days. We observed bipotent common monocytic progenitors (cMoPs), which can differentiate into the monocyte or osteoclast lineage upon macrophage colony-stimulating factor (MCSF) and receptor activator of NF-κB ligand (RANKL) stimulation. Our long-term single cell quantification of cell death and lineage choice reveals that RANKL stimulation instructs cMoPs to commit to the osteoclast lineage. Cell fate decisions of hematopoietic progenitor cells (HSPCs) are controlled by extrinsic signals from their niches. Cytokines promote HSPC survival and/or proliferation. However, whether cytokines can also directly instruct HSPCs to differentiate into specific lineages (lineage instruction model), or only promote the survival and/or proliferation of cells, which have already intrinsically committed to a specific lineage (permissive model), remains disputed. In case of lineage instruction, cytokine signaling would activate the molecular programs initiating lineage choice, thus enabling important insights into its molecular regulation. Despite the fundamental importance of this question, it has not been analyzed for most cell types and cytokines. This is due to the demanding technology required for a quantitative proof: to rule out the exclusively permissive model, all clonal progeny of differentiating HSPCs must be observed throughout their lineage commitment process to exclude even single cell death events. Here, we therefore combined long-term imaging and cell tracking to quantify the cell fates of individual HSPCs and all their progeny over many days. We observed bipotent common monocytic progenitors (cMoPs), which can differentiate into the monocyte or osteoclast lineage upon macrophage colony-stimulating factor (MCSF) and receptor activator of NF-κB ligand (RANKL) stimulation. Our long-term single cell quantification of cell death and lineage choice reveals that RANKL stimulation instructs cMoPs to commit to the osteoclast lineage." @default.
• W4312756594 created "2023-01-05" @default.
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• W4312756594 date "2022-01-01" @default.
• W4312756594 modified "2023-09-30" @default.
• W4312756594 title "3026 – OSTEOCLAST LINEAGE INSTRUCTION BY RANKL SIGNALING" @default.
• W4312756594 doi "https://doi.org/10.1016/j.exphem.2022.07.082" @default.
• W4312756594 hasPublicationYear "2022" @default.
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