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- W4312756852 abstract "Drainage and administration of antibiotics fails in approximately a third of patients with an empyema[1]. The addition of intrapleural Alteplase and Dornase alfa can reduce the collection size, the need for surgical intervention and the length of hospital stay [1]. Most hospitals rely on the duty doctor for the administration of intrapleural medication; who is often not familiar with these, leading to administration delays and errors. To combat this, a new hospital guideline was developed which facilitated senior nurses to be trained in the concurrent administration of intrapleural Alteplase and Dornase alfa. Our aim was to assess if this improved the administration of intrapleural Alteplase and Dornase Alfa in the treatment of an empyema. In a single centre district general hospital, a retrospective case cohort study was undertaken of patients who were administered Alteplase and Dornase alfa for the management of empyema. Data was collected via physical and electronic health records and compared for 7 patients pre and post the introduction of the hospital guideline. The patient populations were similar with 5 males and 2 females in both groups and near average ages (62.9 vs 63.1 years). Overall, there was a decrease in prescription errors (85.7% vs 57.1%), average delay time per dose (122.5 vs 70.9 minutes) and missed doses (5 vs 4). The training of senior nursing staff to administer intrapleural medication led to a significant reduction in the delay time per dose and missed doses. However there were still notable delays. This was most likely due to when trained nursing staff were unavailable. Therefore, training needs to be more widely dispersed to ensure there is always appropriately trained staff." @default.
- W4312756852 created "2023-01-05" @default.
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- W4312756852 date "2022-09-04" @default.
- W4312756852 modified "2023-09-24" @default.
- W4312756852 title "Nursing administration of Alteplase and Dornase Alfa in empyema" @default.
- W4312756852 doi "https://doi.org/10.1183/13993003.congress-2022.76" @default.
- W4312756852 hasPublicationYear "2022" @default.
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