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• W4312758906 abstract "Introduction. Cutaneous and uveal malignant mela­no­mas (MM) show different metastasis characteristics, with no ap­proved systemic treatment for metastatic uveal melanoma. Me­la­no­cytes are particularly susceptible to oxidative stress, defined as an imbalance between the formation of prooxidants and their removal by antioxidant systems. A better understanding of oxidative stress markers (lipid pe­ro­xides, albumin thiols, total antioxidants) differences bet­ween cutaneous and uveal melanoma could be useful in quan­ti­fying the different response to treatment. Materials and method. In a prospective study, 45 patients diagnosed with cutaneous MM (PC), as well as a cohort of 44 patients diag­nosed with uveal MM (PU) were enrolled and separated into three distinct subgroups according to the received treat­ment: radiotherapy (14), enucleation (18), enucleation with postoperative systemic chemotherapy. All patients were followed-up for two years after diagnosis, obtaining seven deter­mi­na­tions of biochemical parameters of oxidative stress – markers of lipid peroxidation inferement via ma­lon­­dial­dehyde measurement, total thiol-albumin groups (Sho­shinsky method), for the inferement of oxidative proteic de­gra­­da­tion. Results. All levels were elevated compared to baseline in cutaneous and uveal melanoma patients: se­rum lipid pe­roxides PC 8.229, PU 8.377 versus baseline 4 µmol/100 ml, serum albumin thiols 511.8 PC, PU 479.9 versus base­line 450 µmol/L, serum total antioxidants 2.768 PC, 3.040 PU versus ba­se­line 1.2 µmol/L, suggesting oxidative stress increase in the presence of a malign tumor. The le­vels in uveal melanoma pa­tients varied more compared to those from cutaneous me­la­noma. Conclusions. The re­sults indicate an increase of lipid peroxidation reaction, se­rum albumin thiols and serum total antioxidants, in cor­re­la­tion with tumor evolution, both in uveal and cu­ta­neous melanoma compared to baseline values. As such, the presence of the tumor is an oxidative stress inductor, with anti-tumor treatment also having the ability to induce oxidative stress through the destruction of tumor cells. Changes between the two groups indicate different molecular signaling mechanisms of endogenous antioxidant activity. They are continuously increasing in cutaneous melanoma, how­ever in uveal melanoma, at the end of the treatment, there is a decrease of recorded serum levels of oxidative pa­ra­meters. It is thus suggested that uveal melanoma leads to the installation of a more pronounced oxidative stress com­pared to cutaneous melanoma, with an intensification of oxygen metabolism and a lower response capacity of the body, possibly related to the increased aggressiveness of this ma­lign cell type. This could explain the increased resistance to immunotherapy of uveal melanoma when compared to cu­taneous melanoma. Our results can be useful in monitoring the tumor evolution under treatment." @default.
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• W4312758906 date "2022-01-01" @default.
• W4312758906 modified "2023-10-14" @default.
• W4312758906 title "Comparaţie între metabolismul oxidativ la pacienţii cu melanom uveal versus melanom cutanat" @default.
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• W4312758906 doi "https://doi.org/10.26416/onhe.60.3.2022.7156" @default.
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