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- W4312778756 abstract "About 40% of patients with diffuse large B-cell lymphoma will develop disease relapse or refractory disease to first-line rituximabcyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy, necessitating second-line therapy. Historically, this consisted of platinum-based chemotherapy followed by autologous stem cell transplantation for patients who were transplant-eligible. But not all patients are eligible for autologous stem cell transplantation and curative treatment options for these patients were limited. The lack of effective treatment options in the relapsed/refractory diffuse large B-cell lymphoma had made the prognosis of these patients poor. In recent years there have been several new therapeutic agents approved or pending approval for the treatment of relapsed/refractory diffuse large B-cell lymphoma. These treatments include antibody- drug conjugates, novel anti CD19 monoclonal antibodies, chimeric antigen receptor T-cell therapy, bispecific antibodies, and selinexor. This paper reviews current strategies and novel therapies for relapsed/refractory diffuse large B cell lymphoma." @default.
- W4312778756 created "2023-01-05" @default.
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- W4312778756 date "2022-01-01" @default.
- W4312778756 modified "2023-09-26" @default.
- W4312778756 title "Relapsed/refractory diffuse large B-cell lymphoma - advancements in treatment" @default.
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- W4312778756 doi "https://doi.org/10.2298/mpns22s1096t" @default.
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