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- W4312794808 abstract "Constipation is a common problem in western societies, but gastrointestinal hypomotility (GIH) assumes greater significance during clozapine therapy for several reasons: GIH is highly prevalent; GIH accounts for 36% of all medically related causes of treatment discontinuation; and in its most severe form, paralytic ileus, there is a fatality rate of 15.0–27.5%. Gastrointestinal illness accounted for 20% of all medically related hospital admissions for clozapine-treated patients at one major US medical center, of which 61% were for hypomotility-related problems. The magnitude of clozapine’s effect on motility is dramatic: the median colonic transit time (CTT) in one study was 23 hours among inpatients on nonclozapine antipsychotics, compared to 104 hours for those on clozapine. Moreover, 80% of the clozapine-treated patients had evidence of GIH, and transit times in all colonic segments were abnormal. Importantly, clozapine-associated GIH occurred irrespective of gender, age, ethnicity, or length of clozapine treatment. Only plasma clozapine level correlated with GIH severity as measured by transit time." @default.
- W4312794808 created "2023-01-05" @default.
- W4312794808 date "2019-05-16" @default.
- W4312794808 modified "2023-09-27" @default.
- W4312794808 title "Managing Constipation" @default.
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- W4312794808 doi "https://doi.org/10.1017/9781108553575.009" @default.
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