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• W4312796119 abstract "AbstractEarly diagnosis and effective treatment are crucial in declining the incidence and favoring the prognosis of cancer. Cancer cells overexpress specific protein biomarkers that can be detected in blood, body fluids, or feces. Early diagnosis of cancerous tumors can be done by the detection of these protein biomarkers. Electrospun nanofibers have been investigated as ultrasensitive biosensors for the diagnosis of specific tumor biomarkers owing to their higher surface-area-to-volume ratio, controllable surface conformation, flexible surface modifications, complex pore structure, and high biocompatibility. Also, they were employed in conjunction with microfluidic techniques to improve the sensitivity and selectivity toward specific biomarkers. Oxygen is a key index in cancer cell biology. Several sensitive oxygen sensors made from electrospun nanofibers have been developed. Another probable way for early cancer detection and to prevent metastasis are the circulating tumor cells, which often are shed from the primary tumor and circulate into the bloodstream, resulting in metastasis to other organs. Surface modification of the electrospun nanofibers with specific functional groups has been used to target and capture the circulating tumor cells. In addition, electrospun coaxial nanofibers had emerged as potential drug delivery carriers. They can be readily loaded with chemotherapeutic agents for their controlled release and localized delivery, achieving effective chemotherapy. Also, in cancer theranostics, the encapsulation of multifunctional nanoparticles into electrospun fibers aids in addressing the shortcomings of burst release profile, instability of multifunctional nanoparticles in an in vivo environment, etc., and probably facilitates simultaneous dual-modal imaging and drug delivery applications. This chapter highlights the role and importance of electrospun nanofibers in cancer research, esp. in the context of diagnosis, detection of circulating tumor cells, construction of 3D tumor models, theranostics, and treatment.KeywordsCirculating tumor cellsCoaxial fibers3D in vitro tumor modelsElectrospinningNanofibers" @default.
• W4312796119 created "2023-01-05" @default.
• W4312796119 creator A5024619257 @default.
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• W4312796119 date "2022-01-01" @default.
• W4312796119 modified "2023-09-27" @default.
• W4312796119 title "Role of Electrospun Nanofibers in Cancer Detection and Treatment" @default.
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• W4312796119 doi "https://doi.org/10.1007/978-3-031-09636-5_9" @default.
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