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• W4312846571 endingPage "179" @default.
• W4312846571 startingPage "151" @default.
• W4312846571 abstract "The arthritides of childhood can be divided into those destructive of connective-tissue elements, especially cartilage, and therefore of function, and those that are transient and nondestructive. There may be many causes of inflammation, but there is probably a single final common pathway leading to joint destruction. In all the destructive arthritides, a stimulus is present within the joint space which: (1) attracts polymorphonuclear cells, (2) causes proliferation of phagocytic synovial-lining cells, and (3) provides material that is phagocytosed. By unknown mechanisms, probably cell death, enzymes capable of destroying cartilage are released from the pathologically increased numbers of phagolysosomes. These degrade proteins, and the resulting polypeptides are themselves chemotactic and inflammatory stimuli. The whole process becomes viciously autocatalytic. The variation between specific diseases probably depends on differences between the original stimuli. In septic arthritis, the stimulus is provided by the invading bacteria. In rheumatoid arthritis and systemic lupus erythematosus, the stimuli are probably antigen-antibody-complement complexes, although infection may play an initiating role. In virus-associated arthritis, the stimulus may be either direct infection or an antigen-antibody complex in which the virus is the antigen. There is no current information about the disease-specific stimuli in the arthritides of acute rheumatic fever or sarcoidosis. Treatment can be aimed at both the specific and shared mechanisms of joint destruction. Current therapy, largely limited to anti-inflammatory agents, probably has its greatest effect on the release and activity of lysosomal enzymes. Specific antibiotics and immunolytic drugs affect disease-specific mechanisms. The latter have limited use for the treatment of arthritis per se and should be applied only to situations involving severe systemic disease." @default.
• W4312846571 created "2023-01-05" @default.
• W4312846571 creator A5083871847 @default.
• W4312846571 creator A5090417492 @default.
• W4312846571 date "1971-01-01" @default.
• W4312846571 modified "2023-09-26" @default.
• W4312846571 title "Mechanisms of Arthritis in Children*" @default.
• W4312846571 cites W120153022 @default.
• W4312846571 cites W126724711 @default.
• W4312846571 cites W1494155214 @default.
• W4312846571 cites W1499305125 @default.
• W4312846571 cites W1500055823 @default.
• W4312846571 cites W1549718609 @default.
• W4312846571 cites W1553179105 @default.
• W4312846571 cites W1698380454 @default.
• W4312846571 cites W1723349763 @default.
• W4312846571 cites W1788017863 @default.
• W4312846571 cites W1890738476 @default.
• W4312846571 cites W1972693022 @default.
• W4312846571 cites W1973405385 @default.
• W4312846571 cites W1976981333 @default.
• W4312846571 cites W1978327790 @default.
• W4312846571 cites W1983717315 @default.
• W4312846571 cites W1984744364 @default.
• W4312846571 cites W1985523461 @default.
• W4312846571 cites W1987973600 @default.
• W4312846571 cites W1988370805 @default.
• W4312846571 cites W1988549846 @default.
• W4312846571 cites W1990659956 @default.
• W4312846571 cites W1992000774 @default.
• W4312846571 cites W1993247327 @default.
• W4312846571 cites W1994135303 @default.
• W4312846571 cites W2000323773 @default.
• W4312846571 cites W2000728769 @default.
• W4312846571 cites W2001128128 @default.
• W4312846571 cites W2001325319 @default.
• W4312846571 cites W2001621485 @default.
• W4312846571 cites W2001774697 @default.
• W4312846571 cites W2006511704 @default.
• W4312846571 cites W2008229497 @default.
• W4312846571 cites W2009224030 @default.
• W4312846571 cites W2009748464 @default.
• W4312846571 cites W2010968630 @default.
• W4312846571 cites W2012636730 @default.
• W4312846571 cites W2014691884 @default.
• W4312846571 cites W2016795447 @default.
• W4312846571 cites W2021894781 @default.
• W4312846571 cites W2024101474 @default.
• W4312846571 cites W2027380091 @default.
• W4312846571 cites W2028729047 @default.
• W4312846571 cites W2029192210 @default.
• W4312846571 cites W2029782398 @default.
• W4312846571 cites W2030694769 @default.
• W4312846571 cites W2031606044 @default.
• W4312846571 cites W2035549922 @default.
• W4312846571 cites W2045491294 @default.
• W4312846571 cites W2046165142 @default.
• W4312846571 cites W2050290035 @default.
• W4312846571 cites W2052019985 @default.
• W4312846571 cites W2052122793 @default.
• W4312846571 cites W2053673472 @default.
• W4312846571 cites W2058533737 @default.
• W4312846571 cites W2060110426 @default.
• W4312846571 cites W2060557528 @default.
• W4312846571 cites W2061146362 @default.
• W4312846571 cites W2062663184 @default.
• W4312846571 cites W2063338465 @default.
• W4312846571 cites W2063409814 @default.
• W4312846571 cites W2065637483 @default.
• W4312846571 cites W2067588713 @default.
• W4312846571 cites W2072608788 @default.
• W4312846571 cites W2072642790 @default.
• W4312846571 cites W2077563248 @default.
• W4312846571 cites W2079343460 @default.
• W4312846571 cites W2079450466 @default.
• W4312846571 cites W2081759481 @default.
• W4312846571 cites W2083826505 @default.
• W4312846571 cites W2086014177 @default.
• W4312846571 cites W2090579615 @default.
• W4312846571 cites W2093605197 @default.
• W4312846571 cites W2095817939 @default.
• W4312846571 cites W2097584864 @default.
• W4312846571 cites W2102191988 @default.
• W4312846571 cites W2105430744 @default.
• W4312846571 cites W2106275418 @default.
• W4312846571 cites W2108056556 @default.
• W4312846571 cites W2110662289 @default.
• W4312846571 cites W2112847060 @default.
• W4312846571 cites W2114337971 @default.
• W4312846571 cites W2136034622 @default.
• W4312846571 cites W2137802513 @default.
• W4312846571 cites W2143914403 @default.
• W4312846571 cites W2144342665 @default.
• W4312846571 cites W2146386129 @default.
• W4312846571 cites W2155240104 @default.
• W4312846571 cites W2162591415 @default.
• W4312846571 cites W2163034106 @default.
• W4312846571 cites W2166101303 @default.

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