Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312869144> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4312869144 endingPage "180" @default.
- W4312869144 startingPage "175" @default.
- W4312869144 abstract "Nontypable Haemophilus influenzae and Moraxella catarrhalis are important pathogens in children and adults. The mechanisms of their adherence to the epithelial cell surface and colonization are not clear. For the pathogen to adhere to the epithelial cell, it must first attach to and penetrate the mucus barrier. Mucin glycoproteins of the mucus layer generally are thought to be involved in bacterial attachment. To understand the precise mechanisms of middle ear mucin‐bacterial interactions, we used an overlay binding assay with a highly purified middle ear mucin and outer membrane proteins of both nontypable H. influenzae and M. catarrhalis. Outer membrane proteins P2 and P5 were identified as the major components that mediate the binding between nontypable H. influenzae and human middle ear mucin. Moreover, the 57 kDa protein, CD, of the outer membrane protein of M. catarrhalis was found to be the only protein binding human middle ear mucin. Finally, it appears that a protein‐oligosaccharide interaction is responsible for binding because asialo‐mucin does not bind to either of the bacteria. Knowledge of the specific bacterial‐mucin interaction may provide an understanding of the bacterial‐epithelial cell colonization. Conversely, comprehension of this interaction between bacteria and purified mucin may be a strategy to prevent colonization of potential pathogens that cause otitis media and sinusitis in children." @default.
- W4312869144 created "2023-01-05" @default.
- W4312869144 creator A5016288860 @default.
- W4312869144 creator A5035252137 @default.
- W4312869144 creator A5050186788 @default.
- W4312869144 creator A5073814443 @default.
- W4312869144 date "1997-02-01" @default.
- W4312869144 modified "2023-10-15" @default.
- W4312869144 title "Middle Ear Mucin Glycoprotein: Purification and Interaction with Nontypable <i>Haemophilus Influenzae</i> and <i>Moraxella Catarrhalis</i>" @default.
- W4312869144 cites W1872355798 @default.
- W4312869144 cites W1893651774 @default.
- W4312869144 cites W1920211617 @default.
- W4312869144 cites W1930768283 @default.
- W4312869144 cites W1980081860 @default.
- W4312869144 cites W2029713105 @default.
- W4312869144 cites W2073879684 @default.
- W4312869144 cites W2080835248 @default.
- W4312869144 cites W2089015231 @default.
- W4312869144 cites W2118852512 @default.
- W4312869144 cites W2149901874 @default.
- W4312869144 cites W2158183641 @default.
- W4312869144 cites W2163969850 @default.
- W4312869144 cites W2178489132 @default.
- W4312869144 doi "https://doi.org/10.1016/s0194-59989770321-8" @default.
- W4312869144 hasPublicationYear "1997" @default.
- W4312869144 type Work @default.
- W4312869144 citedByCount "6" @default.
- W4312869144 countsByYear W43128691442022 @default.
- W4312869144 crossrefType "journal-article" @default.
- W4312869144 hasAuthorship W4312869144A5016288860 @default.
- W4312869144 hasAuthorship W4312869144A5035252137 @default.
- W4312869144 hasAuthorship W4312869144A5050186788 @default.
- W4312869144 hasAuthorship W4312869144A5073814443 @default.
- W4312869144 hasConcept C104317684 @default.
- W4312869144 hasConcept C108625454 @default.
- W4312869144 hasConcept C146587185 @default.
- W4312869144 hasConcept C179264091 @default.
- W4312869144 hasConcept C18903297 @default.
- W4312869144 hasConcept C2776551000 @default.
- W4312869144 hasConcept C2776925733 @default.
- W4312869144 hasConcept C2777312293 @default.
- W4312869144 hasConcept C2910443534 @default.
- W4312869144 hasConcept C501593827 @default.
- W4312869144 hasConcept C523546767 @default.
- W4312869144 hasConcept C54355233 @default.
- W4312869144 hasConcept C547475151 @default.
- W4312869144 hasConcept C55493867 @default.
- W4312869144 hasConcept C86803240 @default.
- W4312869144 hasConcept C89423630 @default.
- W4312869144 hasConceptScore W4312869144C104317684 @default.
- W4312869144 hasConceptScore W4312869144C108625454 @default.
- W4312869144 hasConceptScore W4312869144C146587185 @default.
- W4312869144 hasConceptScore W4312869144C179264091 @default.
- W4312869144 hasConceptScore W4312869144C18903297 @default.
- W4312869144 hasConceptScore W4312869144C2776551000 @default.
- W4312869144 hasConceptScore W4312869144C2776925733 @default.
- W4312869144 hasConceptScore W4312869144C2777312293 @default.
- W4312869144 hasConceptScore W4312869144C2910443534 @default.
- W4312869144 hasConceptScore W4312869144C501593827 @default.
- W4312869144 hasConceptScore W4312869144C523546767 @default.
- W4312869144 hasConceptScore W4312869144C54355233 @default.
- W4312869144 hasConceptScore W4312869144C547475151 @default.
- W4312869144 hasConceptScore W4312869144C55493867 @default.
- W4312869144 hasConceptScore W4312869144C86803240 @default.
- W4312869144 hasConceptScore W4312869144C89423630 @default.
- W4312869144 hasFunder F4320332505 @default.
- W4312869144 hasIssue "2" @default.
- W4312869144 hasLocation W43128691441 @default.
- W4312869144 hasOpenAccess W4312869144 @default.
- W4312869144 hasPrimaryLocation W43128691441 @default.
- W4312869144 hasRelatedWork W1679587214 @default.
- W4312869144 hasRelatedWork W2007643813 @default.
- W4312869144 hasRelatedWork W2045258580 @default.
- W4312869144 hasRelatedWork W2052552936 @default.
- W4312869144 hasRelatedWork W2114205969 @default.
- W4312869144 hasRelatedWork W2119135361 @default.
- W4312869144 hasRelatedWork W2210580558 @default.
- W4312869144 hasRelatedWork W2463163418 @default.
- W4312869144 hasRelatedWork W2488825137 @default.
- W4312869144 hasRelatedWork W4241022394 @default.
- W4312869144 hasVolume "116" @default.
- W4312869144 isParatext "false" @default.
- W4312869144 isRetracted "false" @default.
- W4312869144 workType "article" @default.